Acute hyperkinesia after hypothalamic lesions: A comparison of the time course, level, and type of hyperkinesia induced by ventromedial and lateral hypothalamic lesions in rats

Wiener, Neil I.; Nobrega, JoséN.; Ossenkopp, Klaus‐Peter; Shilman, David M.

doi:10.1016/0014-4886(80)90234-4

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…The role of the VMH in orchestrating the sympathetic nervous system, fat metabolism and exercise benefits has been extensively reviewed 116 . Furthermore, lesions of the VMH cause hyperactivation 117 and an increase in motivation for food in rats 118 . The global germline knockout of SF-1-an abundantly expressed and highly restricted nuclear receptor in the VMH-in female mice causes a significant longterm decrease in physical activity (in terms of wheel turns) 119 .…”

Section: Hypothalamic Control Of Physical Activitymentioning

confidence: 96%

Hypothalamic control of energy expenditure and thermogenesis

et al. 2022

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Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance. The hypothalamus exerts its effect through both humoral and neuronal mechanisms, and each hypothalamic area has a distinct role in the regulation of energy expenditure. Recent studies have advanced the understanding of the molecular regulation of energy expenditure and thermogenesis in the hypothalamus with targeted manipulation techniques of the mouse genome and neuronal function. In this review, we elucidate recent progress in understanding the mechanism of how the hypothalamus affects basal metabolism, modulates physical activity, and adapts to environmental temperature and food intake changes.

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