Acute Hypoglycemic and Antidiabetic Effect of Teuhetenone A Isolated from Turnera diffusa

Parra-Naranjo, Aída; Delgado-Montemayor, Cecilia; Fraga-López, Alejandra; Castañeda-Corral, Gabriela; Salazar‐Aranda, Ricardo; Acevedo-Fernández, Juan José; Waksman, Noemí

doi:10.3390/molecules22040599

Cited by 20 publications

(7 citation statements)

References 21 publications

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“…Likewise, to avoid interference produced by a hyperglycemic event, during the 6 h of the study the animals were deprived of food. 18 Bixa orellana and P. guajava stood out by showing the highest results of hypoglycemic activity at 5 mg kg −1 , an effect similar to that of glibenclamide control. Glibenclamide is a pharmacological agent commonly prescribed for the treatment of T2DM.…”

Section: Discussionmentioning

confidence: 69%

“…Hypoglycemic activity was determined according to the method previously described. 18 CD1 mice (n = 5) without prior fasting were used, and treatments were as follows: (i) insulin (5 IU kg −1 ); (ii) glibenclamide (0.5 mg kg −1 ) as positive control; (iii) negative control was administered only with water; (iv) the different Mayan plant food extracts at doses of 5 and 10 mg kg −1 . The treatments were administered intraperitoneally, and water was used as the vehicle.…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

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Antihyperglycemic and hypoglycemic activity of Mayan plant foods in rodent models

et al. 2021

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BACKGROUND: Postprandial hyperglycemia and decreased insulin secretion are relevant to risk factors in the development of type 2 diabetes and its complications. Plant foods with antidiabetic properties could be an affordable alternative in the prevention and treatment of this disease. In the present study, the antihyperglycemic and hypoglycemic activity of Bixa orellana, Psidium guajava L., Cucurbita moschata, Raphanus sativus L. and Brassica oleracea var. capitata -Mayan plant foodswere evaluated at doses of 5 and 10 mg kg −1 . Antihyperglycemic activity was measured in healthy Wistar rats and those with obesity induced by high-sucrose diet (group HSD) (20%). The hypoglycemic activity was measure in healthy CD1 mice. RESULTS: Fasting glucose, Lee index and the body weight of HSD rats increased significantly (P ≤ 0.05) after 12 weeks of induction compared to healthy rats. In healthy rats, P. guajava and Bixa orellana (10 mg kg −1 ) demonstrated higher and statistically different (P ≤ 0.05) antihyperglycemic activity compared to control acarbose (0.5 mg kg −1 ). In the HSD rat group, all Mayan plant foods (10 mg kg −1 ) demonstrated antihyperglycemic activity statistically equal (P ≤ 0.05) to control acarbose. However, Brassica oleracea and R. sativus registered the highest antihyperglycemic activity. Bixa orellana and P. guajava (5 mg kg −1 ) showed similar hypoglycemic activity (P ≤ 0.05) to glibenclamide (0.5 mg kg −1 ) but was not significant (P ≤ 0.05) compared to insulin (5 UI kg −1 ). CONCLUSION:The present study provides valuable evidence on the possible health benefits of Mayan plant foods. These foods could contribute to the development of therapeutic diet strategies for the prevention and treatment of diabetes.

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Section: Discussionmentioning

confidence: 69%

Section: Hypoglycemic Activitymentioning

confidence: 99%

Antihyperglycemic and hypoglycemic activity of Mayan plant foods in rodent models

et al. 2021

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“…After the single dose of drug administration, blood glucose levels were determined at 0, 1, 2, 4 and 6 h to evaluate acute hypoglycemic effect of the extract as described in the previous study [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Antidiabetic activity, glucose uptake stimulation and α-glucosidase inhibitory effect of Chrysophyllum cainito L. stem bark extract

Doan

Riyajan

Iyara

et al. 2018

BMC Complement Altern Med

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BackgroundChrysophyllum cainito L., a tropical fruit tree, has been used as an alternative medicine for the treatment of diabetic patients in many countries. However, there is very limited scientific rationale for this medical use. The present study aimed to evaluate the antidiabetic activity of the extract from C. cainito stem bark and the possible mechanisms underlying this activity.MethodsPhytochemistry and in vitro antioxidant capacity of the extract were studied. Hypoglycemic activity of the extract was examined in normal and alloxan-induced diabetic mice. The effect of C. cainito extract on glucose absorption and glucose uptake were conducted using mouse isolated jejunum and abdominal muscle, respectively. Finally, an in vitro effect of C. cainito extract on α-glucosidase activity was evaluated.ResultsC. cainito extract possessed a strong antioxidant activity comparable to the ascorbic acid and butylated hydroxytoluene. The extract at 500 mg/kg significantly reduced the area under curve of blood glucose level in oral glucose tolerance test in normal mice. In alloxan-induced diabetic model, similar to glibenclamide, a single dose of the extract significantly decreased fasting blood glucose level from 387.17 ± 29.84 mg/dl to 125.67 ± 62.09 mg/dl after 6 h of administration. From the isolated jejunum experiment, the extract at any doses used did not inhibit glucose absorption. However, the extract at 50 μg/ml significantly increased the amount of glucose uptake by abdominal muscles in the presence of insulin (P < 0.05). Lastly, it was found that the extract produced stronger inhibition of α-glucosidase activity (IC50 = 1.20 ± 0.09 μg/ml) than acarbose (IC50 = 198.17 ± 4.74 μg/ml).ConclusionDirect evidence of antidiabetic activity of C. cainito stem bark with possible modes of action, glucose uptake stimulation and α-glucosidase inhibitory effect, was reported for the first time herein. These data support the potential use of this plant for the treatment of diabetic patients.

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“…Diabetic induction was assessed after three days of alloxan injection. Class II diabetic rats were used in the trial and had glucose levels above 200 mg/dl (survived without insulin) 21 . The rats were divided into five classes at random, as follows.…”

Section: Anti-diabetic Activity In Alloxan-induced Diabetic Ratsmentioning

confidence: 99%

Antidiabetic Activity, Alpha-Amylase and Alpha- Glucosidase Inhibitory Effect of Pastinaca Sativa Extract

Nagaraju

Rajasekhar

et al. 2021

Bulletin of Pharmaceutical Sciences. Assiut

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Pastinaca sativa belonging to the family Apiaceae, is a tropical tree used in many countries as a herbal drug for the care of diabetic patients. However, the methodical rationale for this medical use is very limited. The aim of this analysis was to examine the antidiabetic activity of the Pastinaca sativa methanolic extract and the possible mechanisms underlying that activity. The extract hypoglycemic behavior was investigated in typical diabetic rats induced with alloxan. Finally, an effect of the Pastinaca sativa extract (Crude extract of Pastinaca sativa-CEPS) on the activity of α-amylase and α-glucosidase was examined in vitro. CEPS showed IC50 equal to 91.69 ± 1.5 μg/mL for α-amylase enzyme inhibition activity. Normal acarbose (control) demonstrated IC50 equal to 83.25 ± 1.28 μg/mL. CEPS displayed IC50 values of 88.05 ± 1.25 μg/mL for α-glucosidase enzyme. Under similar laboratory conditions, acarbose displayed an IC50 value of 51.00 ± 1.23 μg/mL. CEPS exhibited IC50 less than 100μg/mL would be considered as healthy. The extract at 400 mg/kg greatly decreased the region under the blood glucose level curve in a typical rats test for oral glucose tolerance. A single dose of the extract decreased significantly in the alloxan-induced diabetic model, similar to glibenclamide (standard), from 208.33 mg/dl to 106.38 mg/dl at 200 mg/kg CEPS and from 209.82 mg/dl to 111.65 mg/dl at 400 mg/kg CEPS. These findings were comparable with 0.5 mg/kg of glibenclamide indicating a substantial decrease from 205.55 mg/dl on 7th day to 84.88 mg/dl. The Pastinaca sativa methanolic extract possesses strong antidiabetic activity in vivo. Besides, the extract has also been shown to have a significant inhibitory activity of αamylase and α-glucosidase, which might lead to its anti-hyperglycemic function when used in diabetic patients.

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Acute Hypoglycemic and Antidiabetic Effect of Teuhetenone A Isolated from Turnera diffusa

Cited by 20 publications

References 21 publications

Antihyperglycemic and hypoglycemic activity of Mayan plant foods in rodent models

Antihyperglycemic and hypoglycemic activity of Mayan plant foods in rodent models

Antidiabetic activity, glucose uptake stimulation and α-glucosidase inhibitory effect of Chrysophyllum cainito L. stem bark extract

Antidiabetic Activity, Alpha-Amylase and Alpha- Glucosidase Inhibitory Effect of Pastinaca Sativa Extract

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