Acute hypoxia increases plasma BDNF but not NGF in healthy young men

Hubold, Christian; Oltmanns, Kerstin M.; Gehring, Hartmut; Schultes, Bernd; Hellweg, Rainer; Schweiger, U.; Born, J. van den; Fehm, HL; Peters, A

doi:10.1055/s-2004-819202

Cited by 1 publication

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“…Regarding the possible effects of controlled hypoxia on BDNF, research so far has provided inconsistent results [20][21][22][23][36][37][38]. However, investigating the effects of daily intermittent normobaric hypoxia over two weeks in young adults in a pilot study, we found reduced BDNF plasma levels [39].…”

Section: Introductionmentioning

confidence: 60%

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline

Duderstadt,

Schreiber,

Burtscher

et al. 2024

Preprint

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: Background: Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neuronal plasticity. Here, we investigated the effects of controlled normobaric hypoxia (NH) combined with physical inactivity on BDNF blood levels and executive functions. Methods: Twenty-five healthy adults (25.8±3.3 years, 15 female) were analyzed in a randomized, controlled cross-over study. Each intervention began with a 30 min resting phase under normoxia (NOR), followed by a 90 min continuation of NOR or NH (peripheral oxygen saturation [SpO2] 85-80%). Serum and plasma samples were collected every 15 min. Heart rate and SpO2 were continuously measured. Before and after each exposure, cognitive tests were performed and after 24 h another follow-up blood sample was taken. Results: NH decreased SpO2 (p<.001, ηp²=.747) and increased heart rate (p=.006, ηp²=.116) significantly. The 30-min resting phase under NOR led to a significant BDNF reduction in serum (p <.001, ηp²=.581) and plasma (p <.001, ηp²=.362). Continuation of NOR further significantly reduced BDNF after another 45 min (p=.018) in serum and after 30 min (p=.040) and 90 min (p=.005) in plasma. There was no significant BDNF decline under NH. 24 h Follow-up examination showed a significant decline of serum BDNF, both after NH and NOR. Conclusion: Our results show that NH has the potential to counteract physical inactivity-induced BDNF decline. Therefore, our study emphasizes the need for a physically active lifestyle and its positive effects on BDNF. This study also demonstrates the need for a standardized protocol for future studies to determine BDNF in serum and plasma.

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