Acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome) following dengue fever

Gonçalves, Eduardo

doi:10.1590/s0036-46652011000400009

Cited by 22 publications

(12 citation statements)

References 8 publications

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“…Zika fetal disorder accounts for the aforementioned complexities along with the neonatal neurological impairment during pregnancy. GBS has been observed to sporadically follow dengue viral infection910 but is apparently more severe in the case of ZIKV due to the incidence of teratogenic lesions11. ZIKV has been identified by PCR in fetuses, and Zika virus particles have been detected by electron microscopy in the fetal central nervous system in high concentrations5.…”

mentioning

confidence: 99%

Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

Mirza

Rafique

Ali

et al. 2016

Sci Rep

102

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The recent outbreak of Zika virus (ZIKV) infection in Brazil has developed to a global health concern due to its likely association with birth defects (primary microcephaly) and neurological complications. Consequently, there is an urgent need to develop a vaccine to prevent or a medicine to treat the infection. In this study, immunoinformatics approach was employed to predict antigenic epitopes of Zika viral proteins to aid in development of a peptide vaccine against ZIKV. Both linear and conformational B-cell epitopes as well as cytotoxic T-lymphocyte (CTL) epitopes were predicted for ZIKV Envelope (E), NS3 and NS5 proteins. We further investigated the binding interactions of altogether 15 antigenic CTL epitopes with three class I major histocompatibility complex (MHC I) proteins after docking the peptides to the binding groove of the MHC I proteins. The stability of the resulting peptide-MHC I complexes was further studied by molecular dynamics simulations. The simulation results highlight the limits of rigid-body docking methods. Some of the antigenic epitopes predicted and analyzed in this work might present a preliminary set of peptides for future vaccine development against ZIKV.

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mentioning

confidence: 99%

Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

Mirza

Rafique

Ali

et al. 2016

Sci Rep

102

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“…It is characterized by ascending paralysis, areflexia, and sensory changes [6]. It is the most common peripheral nervous system complication of dengue fever, and is usually reported during the recovery phase of the illness [12].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with GBS can present with a wide spectrum of clinical manifestations ranging from mild self-limiting disease to acute fulminant cases with respiratory paralysis [5]. Compared with other infections such as Campylobacter jejuni and cytomegalovirus, dengue fever is an uncommon antecedent of GBS and only a few cases have been reported [6789]. Here, we report two cases of dengue fever complicated by GBS.…”

Section: Introductionmentioning

confidence: 99%

Guillain–Barré syndrome complicating dengue fever: Two case reports

Boo

Aris

Chin

et al. 2016

Tzu Chi Medical Journal

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“…Our results are consistent with previous studies 14,15 . Earlier clinical case studies reported dengue preceding GBS [20][21][22][23][24][25][26] . Our findings further showed that there is a cross-correlation between GBS and dengue cases.…”

Section: Discussionmentioning

confidence: 99%

Analysing Trends of Guillain-Barre Syndrome (GBS)and Dengue cases in Hong Kong

Wang

2018

OJPHI

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Objective: To study the trends of GBS and dengue in Hong Kong, the ecological associations between GBS, dengue, and local meteorological factors. To examine the non-stationary oscillating association among these factors.Introduction: Guillain-Barre Syndrome (GBS) is a severe paralytic neuropathy associated with virus infections such as Zika virus and Chikungunya virus. There were also case reports of dengue fever preceding GBS. With the aim to understand the mechanisms of GBS and dengue outbreaks, this ecological study investigates the relationships between GBS, dengue,meteorological factors in Hong Kong and global climatic factors from January 2000 to June 2016.Methods: The correlations between GBS, dengue, Multivariate El Nino Southern Oscillation Index (MEI) and local meteorological data were explored by Spearman's Rank correlations and cross-correlations. Three Poisson regression models were fitted to identify non-linear associations among GBS, dengue and MEI. Cross wavelet analyses were applied to infer potential non-stationary oscillating associations among GBS, dengue and MEI.Results: We found a substantial increasing of local GBS and dengue cases (mainly imported) in recent year in Hong Kong. The seasonalities of GBS and dengue are different, in particular, GBS is low while dengue is high in the summer. We observed weak but significant correlations between GBS and local meteorological factors. MEI could explain over 17% of dengue's variations based on Poisson regression analyses. We report a possible non-stationary oscillating association between dengue fever and GBS cases in Hong Kong.Conclusions: We report increasing patterns of both local GBS cases and imported dengue cases in Hong Kong, and investigate the possible mechanism behind these patterns.This study has led to an improved understanding about the timing and ecological relationships between MEI, GBS and dengue.

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Acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome) following dengue fever

Cited by 22 publications

References 8 publications

Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

Guillain–Barré syndrome complicating dengue fever: Two case reports

Analysing Trends of Guillain-Barre Syndrome (GBS)and Dengue cases in Hong Kong

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