Acute Interstitial Nephritis Associated With Uveitis and Primary Hypoparathyroidism

Catalano, Carlo; Harris, Philip E.; Enia, Giuseppe; Pastorino, Maurizio; Martorano, C.; Maggiore, Q

doi:10.1016/s0272-6386(89)80212-4

Cited by 34 publications

(21 citation statements)

References 6 publications

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“…An association with a hypoparathyroidism [33]; lymphoid interstitial lung disease with alveolitis [34]; hyperthyroidism [35]; Cogan's syndrome [36] and IgG 4 related syndrome [37] has been reported. There are few reports of patients with TINU syndrome who had family members suffering from autoimmune diseases, including a father with Vogt-Koyanagi-Harada syndrome and sister with ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome, Two New Cases and Review of the Literature

Laidoudi¹,

Hakem²

2016

J Nephrol Ther

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Case 1: A 25 year-old woman, presented with asthenia; weight loss; severe hypertension and acute unilateral anterior uveitis. She had also proteinuria; hematuria; aciduria; kidney failure and grade I hypertensive retinopathy. Kidney biopsy showed a non caseating granuloma in the interstitial tissue, and tubulointerstitial nephritis (TIN) with granulomatous lesions in the medullary parenchyma. All explorations were negative but QuantiFERON was 10 times normal without koch's bacillus. No other sites of granulomas. The patient partially responded to corticoid treatment. She replased after untimely stopping corticosteroids. Corticosteroid-sparing was provided by mycophenolate mofetil.Case 2: A 46 year-old patient, with family history of mother who died of CKD, presented with recurrent anterior uveitis, kidney failure, proteinuria, and inflammatory syndrome, research of infectious agents or auto-immunity origin was negative. Renal biopsy showed TIN lesions in subacute stage; biopsy of the salivary glands showed stage III chronic lymphocytic sialadenitis without Sjogren syndrome or sarcoidosis. The patient received corticosteroid treatment. Discussion:The presence of TIN, recurrent anterior uveitis, no notion of drug intake, response to corticosteroids and exclusion of other diagnoses leads to TINU syndrome. Positivity of Quantiferon is explained by the fact that TINU syndrome is associated with high serological markers in the absence of their corresponding diseases, and presence of chronic lymphocytic sialadenitis explained by these immunological disorders without Sjogren syndrome, Both patients remained well without recurrence of uveitis 2 and 6 years later respectively. Conclusion:TINU syndrome is secondary to immunological disorders as evidenced interstitial infiltrate of the renal parenchyma, the inflammatory disease of the uvea and good response to corticosteroid therapy.

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Section: Discussionmentioning

confidence: 99%

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome, Two New Cases and Review of the Literature

Laidoudi¹,

Hakem²

2016

J Nephrol Ther

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“…An association between idiopathic AIN, uveitis and idiopathic hypoparathyroidism has been recognised [1,2]. This is the first report of an association between idiopathic AIN and idiopathic cranial DI.…”

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confidence: 78%

Acute Interstitial Nephritis and Idiopathic Cranial Diabetes Insipidus

Chan¹,

Kung²,

Chan

et al. 1992

Nephron

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“…Although hypergammaglobulinemia is universally ob served in patients with this syndrome, and autoantibod ies, including rheumatoid factor [3,14,19] and ANA [4] have been found in some patients, a clear-cut immunolog ical disturbance has not been found until now. It is unlike ly that humoral immune mechanisms, such as anti-tubular basement membrane antibodies or immune com plexes, induce AIN because immunofluorescence studies of the tubules and interstitium have been negative in all patients including our case.…”

Section: Discussionmentioning

confidence: 99%

Acute Interstitial Nephritis and Uveitis with Bone Marrow Granulomas and Anti-IMeutrophil Cytoplasmic Antibodies

et al. 1995

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Acute interstitial nephritis (AIN) and uveitis of unknown etiology developed in a 15-year-old girl. Symptoms and urinary abnormalities improved spontaneously but moderate renal dysfunction and anterior uveitis persisted. A repeat biopsy performed 2 years later showed focal tubulointerstitial changes, while bone marrow examination revealed granulomas. Simultaneously, anti-neutrophil cytoplasmic antibodies (ANCA) were detected, and decreases in T cell population and lymphocyte function were found. These immunological abnormalities normalized in parallel with clinical improvement with corticosteroid therapy, strongly suggesting that in some patients autoimmune disorders contribute to the pathogenesis of the disease.

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Acute Interstitial Nephritis Associated With Uveitis and Primary Hypoparathyroidism

Cited by 34 publications

References 6 publications

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome, Two New Cases and Review of the Literature

Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome, Two New Cases and Review of the Literature

Acute Interstitial Nephritis and Idiopathic Cranial Diabetes Insipidus

Acute Interstitial Nephritis and Uveitis with Bone Marrow Granulomas and Anti-IMeutrophil Cytoplasmic Antibodies

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