Acute interstitial pneumonia as first presentation of anti-synthetase syndrome: an atypical case

Jan, Kalimullah; Sriranganathan, Melonie K

doi:10.1093/omcr/omy003

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Total 30 cases reported, 17 male patients and 13 female patients. Only 43% of the cases presented with lung symptoms alone [2,4,7,10,[16], [17], [18],[23], [24], [25],29,32], while 57% of the cases presented with lung and muscle symptoms simultaneously [1,5,8,[11], [12], [13], [14], [15],[19], [20], [21], [22],[26], [27], [28],30,31]. We did not review any cases that presented with muscle symptoms alone.…”

Section: Resultsmentioning

confidence: 99%

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Acute hypoxic respiratory failure secondary to antisynthetase syndrome: A case report and review of literature

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Song

2019

Respiratory Medicine Case Reports

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Objective Antisynthetase syndrome is a condition that includes interstitial lung disease and inflammatory myositis in its definition. The interstitial lung disease of this syndrome can vary in severity and if not identified soon enough, can lead to severe respiratory failure. Here we present a patient who had a working diagnosis of acute eosinophilic pneumonia. He initially improved after prolonged hospitalization and course of high dose steroids. CT chest revealed interval improvement in his bilateral ground glass and reticular opacities but residual fibrotic interstitial lung disease. However, he decompensated subsequently with relapsed hypoxia during activity. We hope that this review will bring awareness to antisynthetase syndrome and provide tools for earlier diagnosis and treatment. The primary objective of this study was to review presenting symptoms, diagnosis, treatment and outcomes. This review is unique because we focused on antisynthetase syndrome that initially manifested with lung symptoms rather than myositis or skin changes. Methods We have performed a comprehensive review of 30 cases of antisynthetase syndrome in the literature (including our case). Results Total 30 cases reported, 17 male patients and 13 female patients. Only 43% of the cases presented with lung symptoms alone, while 57% of the cases presented with lung and muscle symptoms simultaneously. Conclusion This supports the fact that antisynthetase syndrome most commonly presents with lung and muscle manifestations simultaneously. The fact that our case presented with lung findings alone led to the delay in his diagnosis.

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Section: Resultsmentioning

confidence: 99%

“…High resolution CT scan of the chest is most commonly done when interstitial lung disease is suspected. The most common findings on CT scan include ground glass opacifications, peribronchial consolidations and find nodularity [7]. Fibrosis is a negative prognostic indicator in antisynthetase syndrome [8].…”

Section: Discussionmentioning

confidence: 99%

Acute hypoxic respiratory failure secondary to antisynthetase syndrome: A case report and review of literature

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Song

2019

Respiratory Medicine Case Reports

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“…94 Cyclophosphamide is an effective alternative agent in severe cases. 95,96 Rituximab is the most widely reported biological agent used in the treatment of AS-ILD, particularly as rescue therapy in severe or refractory cases. Recently, 25 patients with AS-ILD (84% were recurrent or refractory cases) treated with rituximab from 2 medical centers in the United States were retrospectively reviewed by Doyle et al 97 The CT score and FVC were stable or improved at 12 months compared with baseline in 88% and 79% of participants, respectively.…”

Section: Dm/pm-and As-ildmentioning

confidence: 99%

Treatment of the Connective Tissue Disease–Related Interstitial Lung Diseases: A Narrative Review

Gao

Moua

2020

Mayo Clinic Proceedings

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Interstitial lung disease (ILD) is a frequent complication of patients with connective tissue disease (CTD) and significantly affects morbidity and mortality. Disease course may vary from stable or mildly progressive to more severe, with rapid loss of lung function. We conducted a search of PubMed (National Library of Medicine) and the Web of Science Core Collection using the key words lung, pulmonary, pneumonia, pneumonitis, and alveolar and subtypes of CTD. All clinical studies from January 1, 1980, through September 1, 2018, were reviewed for descriptions of specific therapies and their efficacy or safety and were categorized as controlled interventional trials, observational prospective or retrospective cohort studies, case series (>5 patients), and case reports (<5 patients). Lowquality reports (<5 patients) before 2000, reviews, editorials, popular science papers, and letters to the editor without complete descriptions of the therapies used or their outcomes were excluded. Directed therapy for CTD-ILD is dominated by empirical use of immunosuppressive agents, with the decision to treat, treatment choice, and treatment duration limited to cases and cohort observations. Only a few higher-level controlled studies were available specifically in scleroderma-related ILD. We summarize herein for the clinician the published treatment scope and experience, highlighted clinical response, and common adverse reactions for the management of CTD-ILD.

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AIP, Jo-1 and ECMO

Vijayasingam

Alcalde

Shah

et al. 2018

Thorax

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Acute interstitial pneumonia as first presentation of anti-synthetase syndrome: an atypical case

Cited by 3 publications

References 9 publications

Acute hypoxic respiratory failure secondary to antisynthetase syndrome: A case report and review of literature

Acute hypoxic respiratory failure secondary to antisynthetase syndrome: A case report and review of literature

Treatment of the Connective Tissue Disease–Related Interstitial Lung Diseases: A Narrative Review

AIP, Jo-1 and ECMO

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