Acute Ischemic Stroke in a Young Woman with an Otherwise Asymptomatic SARS-CoV-2 Infection

Abstract

It was well-observed that SARS-CoV-2 may cause a hypercoagulable state in hospitalized patients. Often these hospitalized patients exhibit severe upper respiratory symptoms with hypoxia, requiring high amounts of oxygen support. In this study, we report a young healthy 30-year-old woman with no medical problems, who experienced an embolic stroke due to an otherwise asymptomatic SARS-CoV-2 infection in July 2020. The patient presented to the emergency department after experiencing sudden slurred speech, dizziness, and acute left leg weakness during a social gathering on a river boat the day prior to admission. She also vomited once, non-bilious. The patient had no upper respiratory symptoms and had not been practicing social distancing nor wearing a mask. She did not have any sick contacts or significant travel history. Patient used oral contraceptives but never smoked. The workup included a Computed Tomography (CT) angiogram, an Magnetic Resonance Imaging (MRI) and an Magnetic Resonance Angiography (MRA) of the brain. It was significant for acute stroke with acute intraluminal thrombus causing partial occlusion of the distal basilar artery with left pontine stroke. Given that the onset of symptoms was greater than 4 hours, she was outside of the tissue Plasminogen Activator (tPA) administration window. Patient was also not a candidate for embolectomy as National Institute of Health Stroke Scale (NIHSS) was 3 and the occlusion was partial. SARS-CoV-2 PCR test was positive. D-Dimer level was elevated but CRP was normal. Echocardiogram was unremarkable. The patient had no history of autoimmune disorder. Patient was initially treated with antiplatelet medications aspirin and clopidogrel (Plavix). Her condition improved and she could ambulate with a front wheel walker and stand by to assist. She was discharged four days later with anticoagulation medication rivaroxaban (Xarelto) for 3 months. This case illustrates that patients with an otherwise asymptomatic SARS-CoV-2 infection may still suffer from complications of SARS-CoV-2. Do women on oral contraceptives have higher risk of arterial embolism when infected with SARS-CoV-2? More study is needed.

Different COVID-19 treatments’ impact on hospital length of stay

“…In addition, within the past 2 years, we have seen acute ischemic stroke as a complication of patients with severe SARS-CoV-2 infection due to its precipitation of a hypercoagulable state [ 34 ]. There has even been a reported case of stroke in a young healthy woman with an asymptomatic SARS-CoV-2 infection as well [ 35 ]. Studies have shown that in-hospital treatment with heparin was associated with lower mortality in severe COVID-19 patients [ 36 ].…”

“…While it is a disease that mainly involves the lungs, multiple organs, including neurological symptoms, have been described frequently [ 3 ]. Even young adults with seemingly asymptomatic COVID-19 infections can end up suffering a thrombotic stroke that adversely affects their health [ 4 ]. Currently, there is no definitive antiviral agent to treat hospitalized patients with severe COVID-19 [ 5 ].…”