2019
DOI: 10.7883/yoken.jjid.2018.494
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Acute Liver Failure Associated with Influenza A Virus Infection: an Autopsy Case Report

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Cited by 9 publications
(10 citation statements)
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“…Hypoxic hepatitis was a clinical characteristic in the H7N9 infection [9]. Recent data further confirmed that hypoxic hepatitis can be an important causative factor for acute liver failure associated with influenza virus infection instead of virus related hepatitis [19]. We know that highly pathogenic influenza virus leads to respiratory failure, which reduces the oxygen supply to the liver, and hypoxic hepatitis is a likely cause of severe liver impairment in our study.…”
Section: Discussionsupporting
confidence: 75%
“…Hypoxic hepatitis was a clinical characteristic in the H7N9 infection [9]. Recent data further confirmed that hypoxic hepatitis can be an important causative factor for acute liver failure associated with influenza virus infection instead of virus related hepatitis [19]. We know that highly pathogenic influenza virus leads to respiratory failure, which reduces the oxygen supply to the liver, and hypoxic hepatitis is a likely cause of severe liver impairment in our study.…”
Section: Discussionsupporting
confidence: 75%
“…6 Otherwise, the severe hypoxia associated with pneumonia, could also contribute to liver injury, or even develop into liver failure in patients who are seriously ill by pre-existing chronic conditions of impairment, as it happens in other clinical settings. 53 Liver and kidney functions, devoted to pharmacological de-toxification and excretion, may be compromised by therapeutic agents for COVID-19 treatment. It is also possible that liver failure is due to the drug's hepatotoxicity, which can be explained based on the variability observed in the various cohorts analysed until now.…”
Section: Liver Diseasementioning
confidence: 99%
“…In fact, an imbalance between coagulation and fibrinolysis during severe influenza has been confirmed in mouse and ferret models 6 , 7 . Furthermore, the increased risk of acute myocardial infarction and venous thromboembolism after acute infectious diseases, including influenza, and the prolonged prothrombin time (PT) in human clinical cases further suggest that abnormal blood coagulation caused by viral infection also occurs in humans 4 , 8 10 . Therefore, the elucidation of the detailed mechanisms of abnormal blood coagulation during severe influenza would provide novel and important insights into the further understanding of influenza pathogenesis.…”
Section: Introductionmentioning
confidence: 99%