Acute Liver Failure Caused by Primary Non-Hodgkin's Lymphoma of the Liver

López, Laura Romacho; Díaz, F.; Pérez, B. Sánchez; Daga, J.A. Pérez; Aguilar, José Luis Fernández; Casado, María Custodia Montiel; Narváez, José Manuel Aranda; Muñóz, Miguel Ángel Suárez; Santoyo-Santoyo, Julio

doi:10.1016/j.transproceed.2016.10.005

Cited by 7 publications

(1 citation statement)

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“…Jaundice is rare and present in less than 5% of patients (18) . Rarely, the disease may have acute presentations including abdominal pain (19) or acute liver failure (20) . In our series the classic B-cell symptoms (fever, weight loss, night sweats) were commonly reported.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Characterization of Hepatic Lymphomas: A Retrospective Single-Center Study

Dias

Marques

Gonçalves

et al. 2023

Arq. Gastroenterol.

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Background: The incidence of hepatic lymphoma has been increasing recently and diagnosis can be challenging as clinical presentation and radiological findings are usually variable and non-specific. Objective The aims of this study were to describe their main clinical, pathological and imaging characteristics and identify poor prognostic factors. Methods A retrospective study that included all patients with histological diagnosis of liver lymphoma over a 10-year period at our center was performed. Results A total of 36 patients were identified, with mean age of 56.6 years and male predominance (58%). There were three patients with primary liver lymphoma (8.3%) and 33 with secondary liver lymphoma (91.7%). The most common histological type was diffuse large B-cell lymphoma (33.3%). The most common clinical manifestations included fever, lymphadenopathy, weight loss, night sweats and abdominal discomfort; three patients (11.1%) were asymptomatic. Computed tomography scan revealed heterogenous radiological patterns including a single nodule (26.5%), multiple nodules (41.2%) or diffuse infiltration (32.4%). The mortality rate during follow-up was 55.6%. Higher levels of C-reactive protein (P=0.031) and absence of treatment response (P<0.001) were significantly associated with higher mortality. Conclusion Hepatic lymphoma is a rare disease that may involve liver as part of a systemic disease or, less commonly, be confined to this organ. Clinical presentation and radiological findings are often variable and non-specific. It is associated with high mortality and poor prognostic factors include higher levels of C-reactive protein and absence of response to treatment.

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Section: Discussionmentioning

confidence: 99%