Acute Liver Failure Induced by  Carthamus tinctorius  Oil: Case Reports and Literature Review

Ataíde, Elaine Cristina de; Perales, Simone Reges; Peres, Marco Antonio de Oliveira; Costa, Larissa Bastos Eloy da; Quarella, F.; Valerini, Felipe Gilberto; Neto, Felício Chueiri; Stucchi, Raquel Silveira Bello; Boin, Ilka de Fátima Santana Ferreira

doi:10.1016/j.transproceed.2018.01.010

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…No adverse reactions were observed in mice with a dose of 400 mg/kg [19] Carthamus tinctorius L., safflower, Hong Hua, 3-10 g e flowers of safflower contain kaempferol and hydroxysafflor yellow [20] It reduces immune inflammatory response [14]. Carthamus tinctorius (safflower) oil is used as a dietary supplement for weight loss and antioxidant [21] 3 patients had a diagnosis of acute liver failure, while consumed safflower as a dietary supplement for weight loss [21] Terminalia chebula Retz., Ke Zi, 3-10 g…”

Section: Size Of Neoplasmmentioning

confidence: 99%

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Xue

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. Methods. Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured. Results. After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, P=0.038), and the pain scores were markedly reduced (P=0.004). Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α. Conclusion. External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744.

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Section: Size Of Neoplasmmentioning

confidence: 99%

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Xue

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Considering the strong correlation between Safflower and Sappan Wood, they were considered to be the same crude drug group when calculating RORs, which we found to be the third-highest. Although some reports showed an association between Safflower and acute liver failure [ 19 ], many other reports revealed that the components in Safflower reduce hepatotoxicity and exhibit hepatoprotective effects [ 20 , 21 , 22 , 23 ]. No reports of hepatotoxicity in Sappan Wood were found.…”

Section: Discussionmentioning

confidence: 99%

Identifying Crude Drugs in Kampo Medicines Associated with Drug-Induced Liver Injury Using the Japanese Adverse Drug Event Report Database: A Comprehensive Survey

et al. 2023

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The current study aimed to identify the crude drugs associated with drug-induced liver injury (DILI) in 148 Kampo medicines prescribed throughout Japan using the Japanese Adverse Drug Event Report (JADER) database, a large-scale spontaneous reporting system in Japan. First, we tabulated the number of DILI reports from the report-based dataset and the background information from the patient-based dataset. Thereafter, we combined the 126 crude drugs into 104 crude drug groups to examine multicollinearity. Finally, the reporting odds ratios (RORs), 95% confidence intervals, p values for Fisher’s exact test, and number of reports were calculated for each crude group to identify those associated with DILI. Notably, the number of adverse event reports for DILI (63,955) exceeded that for interstitial lung disease (51,347), the most common adverse event. In total, 78 crude drug groups (90 crude drugs) were reported to have an ROR > 1, a p < 0.05, and ≥10 reported cases. Our results highlight DILI as an essential issue, given that it was among the most frequently reported adverse drug reactions. We were able to clearly identify the crude drugs associated with DILI, which could help manage adverse drug reactions attributed to Kampo medicines and crude drugs.

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“…Nevertheless, the most adverse events of SM were mild to moderate and cleared up after SM treatment withdrawal. Carthamus tinctorius L. [Asteraceae], with the efficacy of activating blood and resolving stasis, led to acute liver failure (ALF) in a few patients ( de Ataide et al, 2018 ). In addition, the kidney-tonifying botanical drug, Cullen corylifolium (L.) Medik.…”

Section: Deficiencies Of Chinese Medicines In Stem Cell Therapymentioning

confidence: 99%

Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction

Wang

Xue²,

Guo³

2022

Front. Pharmacol.

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Cardiovascular diseases are the leading cause of global mortality, in which myocardial infarction accounts for 46% of total deaths. Although good progress has been achieved in medication and interventional techniques, a proven method to repair the damaged myocardium has not yet been determined. Stem cell therapy for damaged myocardial repair has evolved into a promising treatment for ischemic heart disease. However, low retention and poor survival of the injected stem cells are the major obstacles to achieving the intended therapeutic effects. Chinese botanical and other natural drug substances are a rich source of effective treatment for various diseases. As such, numerous studies have revealed the role of Chinese medicine in stem cell therapy for myocardial infarction treatment, including promoting proliferation, survival, migration, angiogenesis, and differentiation of stem cells. Here, we discuss the potential and limitations of stem cell therapy, as well as the regulatory mechanism of Chinese medicines underlying stem cell therapy. We focus on the evidence from pre-clinical trials and clinical practices, and based on traditional Chinese medicine theories, we further summarize the mechanisms of Chinese medicine treatment in stem cell therapy by the commonly used prescriptions. Despite the pre-clinical evidence showing that traditional Chinese medicine is helpful in stem cell therapy, there are still some limitations of traditional Chinese medicine therapy. We also systematically assess the detailed experimental design and reliability of included pharmacological research in our review. Strictly controlled animal models with multi-perspective pharmacokinetic profiles and high-grade clinical evidence with multi-disciplinary efforts are highly demanded in the future.

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Acute Liver Failure Induced by Carthamus tinctorius Oil: Case Reports and Literature Review

Cited by 8 publications

References 4 publications

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Identifying Crude Drugs in Kampo Medicines Associated with Drug-Induced Liver Injury Using the Japanese Adverse Drug Event Report Database: A Comprehensive Survey

Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction

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