Acute lymphoblastic leukemia (ALL) with t(8;14)(q11.2;q32) in an elderly patient

C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?

“…Translocations involving c-myc on chromosome 8q have been described, rarely, in cases of B-ALL with multiple translocation partners including the IGH locus at 14q32 [27,28]. While gains of chromosome 8 were more common in patients with c-myc ≥10%, majority of patients with high c-myc expression did not have any chromosome 8 abnormalities by conventional cytogenetics.…”

Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research

“…The t(8;14) is a rare recurrent abnormality among patients with ALL [20][21][22][23] and has been associated with a poor outcome. 7 It was observed in ten allogeneic HCT recipients (median age, 21) who had a nearly 3-fold significantly lower leukemia-free survival in our cohort.…”