Acute Magnetic Resonance Imaging Predictors of Chronic Motor Function and Tissue Sparing in Rat Cervical Spinal Cord Injury

Lee, Seung-Yi; Schmit, Brian D.; Kurpad, Shekar N.; Budde, Matthew D.

doi:10.1089/neu.2022.0034

Cited by 8 publications

(9 citation statements)

References 49 publications

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“…48 A handful of published rodent studies have shown fDWI is more accurate than DTI in predicting postinjury locomotor scores. 20,44 In agreement with these studies, we found that the D axial was significantly diminished 4 h after injury and strongly predicted locomotor and lower urinary tract (LUT) recovery (Fig. 8A).…”

Section: Discussionsupporting

confidence: 86%

“…The subsequent detection of diffusion parallel to the cord (D axial ) with filter is believed to be more reflective of axonal injury associated with focal varicosities or beading that occurs in injured axons 48 . A handful of published rodent studies have shown fDWI is more accurate than DTI in predicting postinjury locomotor scores 20,44 . In agreement with these studies, we found that the D axial was significantly diminished 4 h after injury and strongly predicted locomotor and lower urinary tract (LUT) recovery (Fig.…”

Section: Discussionsupporting

confidence: 80%

“…Axonal injury is considered a more accurate predictor of neurological outcome. 17 Diffusion tensor imaging (DTI) is an MRI technique that has shown promise in estimating the degree of axonal injury in acutely injured cords in animal [18][19][20][21] and some human studies. 17,22,23 In addition, fractional anisotropy (FA), a key DTI parameter that is reduced in acute SCI, is confounded by edema and hemorrhage, making its interpretation and reliability in critical SCI evaluation problematic.…”

Section: Introductionmentioning

confidence: 99%

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Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury

Ahmed,

Medina‐Aguinaga,

Adams

et al. 2023

Ann Clin Transl Neurol

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ObjectivesTo explore filtered diffusion‐weighted imaging (fDWI), in comparison with conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), as a predictor for long‐term locomotor and urodynamic (UD) outcomes in Yucatan minipig model of spinal cord injury (SCI). Additionally, electrical conductivity of neural tissue using D‐waves above and below the injury was measured to assess correlations between fDWI and D‐waves data.MethodsEleven minipigs with contusion SCI at T8‐T10 level underwent MRI at 3T 4 h. post‐SCI. Parameters extracted from region of interest analysis included Daxial from fDWI at injury site, fractional anisotropy and radial diffusivity from DTI above the injury site along with measures of edema length and cord width at injury site from T2‐weighted images. Locomotor recovery was assessed pre‐ and weekly post‐SCI through porcine thoracic injury behavior scale (PTIBS) and UD were performed pre‐ and at 12 weeks of SCI. D‐waves latency and amplitude differences were recorded before and immediately after SCI.ResultsTwo groups of pigs were found based on the PTIBS at week 12 (p < 0.0001) post‐SCI and were labeled “poor” and “good” recovery. D‐waves amplitude decreased below injury and increased above injury. UD outcomes pre/post SCI changed significantly. Conventional MRI metrics from T2‐weighted images were significantly correlated with diffusion MRI metrics. Daxial at injury epicenter was diminished by over 50% shortly after SCI, and it differentiated between good and poor locomotor recovery and UD outcomes.InterpretationSimilar to small animal studies, fDWI from acute imaging after SCI is a promising predictor for functional outcomes in large animals.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury

Ahmed,

Medina‐Aguinaga,

Adams

et al. 2023

Ann Clin Transl Neurol

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“…Longitudinal studies showed that FA in infarcts decreased gradually from the acute to the subacute phase, while MD initially decreased and then increased (Kern et al, 2022). Decreased FA might be related CST axonal damage and degeneration (Chang et al, 2017), and increased MD might be associated with vasogenic edema after stroke (Kern et al, 2022;Lee S.-Y. et al, 2022), which has a great impact on motor dysfunction after stroke.…”

Section: Association Between Damaged Glymphatic System and Cst In Str...mentioning

confidence: 99%

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Qin

Li²,

Qiao

et al. 2023

Front. Neurosci.

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PurposeBrain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients.MethodsTwenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively.ResultsSix IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group (t = −3.02, p = 0.004). In the IS group, a positive correlation between the left DTI-ALPS index and the simple Fugl-Meyer motor function score (ρ = 0.52, p = 0.019) and a significant negative correlation between the left DTI-ALPS index and the FA (R = −0.55, p = 0.023) and MD (R = −0.48, p = 0.032) values of the right CST were found.ConclusionsGlymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS.

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“…Vertebro-medullary trauma (VMT) causes osteo-articular injuries of the vertebrae and their contents (marrow, nerve roots, meninges and vessels) in a varied anatomical lesional association, with multiple clinical manifestations and therapeutic indications [ 1 ]. The occurrence of a spinal cord injury (SCI) causes a disability that can manifest itself in different levels of severity, the patient having difficulties in the family, social and economic context of functioning and integration [ 2 , 3 ]. SCI patients face poor financial situations and poor socio-economic achievements, and the life expectancy of the disabled person is much lower [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Advantages and Limitations in the Evaluation of the Neurological and Functional Deficit in Patients with Spinal Cord Injuries

Lascu

Buhaş

Mekereș

et al. 2022

Clinics and Practice

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(1) Background: Vertebro-medullary trauma (VMT) causes osteo-articular injuries in a varied anatomical lesion associated with multiple clinical manifestations and therapeutic indications. The neurological evaluation of patients who have suffered a spinal cord injury (SCI) is costly in testing the motor and sensory function. To standardize the assessment, several scales are used that measure the neurological deficit in order to guide subsequent treatment according to complete or incomplete SCI. The aim of this study is to identify and present the relevant tools for assessing SCI. (2) Methods: Relevant SCI studies were used for a fact-finding investigation from a rational and critical perspective of this field of research. The relationship between clinical tools and those with a psychosocial component was assessed based on studies reported in the literature. (3) Results: SCI severity scales have been proposed throughout to be able to estimate the functional prognosis of victims of these traumatic events. These tools can be divided into scales for assessing the neurological deficit due to trauma, and functional scales that assess the ability to perform daily activities, self-care, etc. (4) Conclusions: The closest scale to the need for standardization and the most accurate assessment of neurological deficits secondary to SCI is ASIA/IMSOP.

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Acute Magnetic Resonance Imaging Predictors of Chronic Motor Function and Tissue Sparing in Rat Cervical Spinal Cord Injury

Cited by 8 publications

References 49 publications

Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury

Predictive values of spinal cord diffusion magnetic resonance imaging to characterize outcomes after contusion injury

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Advantages and Limitations in the Evaluation of the Neurological and Functional Deficit in Patients with Spinal Cord Injuries

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