Acute Manson's schistosomiasis

Diaz-Rivera, R S; Ramos‐Morales, Francisco; Koppisch, E.; García-Palmieri, Mario R.; Cintrón-Rivera, A.A.; Marchand, Ernesto J.; González, Omar; Torregrosa, Mercedes Vicente De

doi:10.1016/0002-9343(56)90107-3

Cited by 62 publications

(13 citation statements)

References 21 publications

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“…Microvacuolated hepatocytes were visible adjacent to the eggs, coagulative necrosis was evident, and the area was surrounded by eosinophils (9 (215). Clinical manifestations seen in patients, i.e., skin rash, eosinophilia, pulmonary edema, or diarrhea, are consistent with this contention (36,106,234). The temporal relationship between the appearance of symptoms and the release into the circulation of large amounts of worm antigens derived from VOL.…”

Section: Introductionmentioning

confidence: 63%

“…The acute (toxemic) syndrome is manifested by fever, malaise, hepatosplenomegaly, eosinophilia, diarrhea, and, in some cases, edema, urticaria. lymphadenopathy, and arthralgia (106,200,234,277). These symptoms are transient and spontaneously disappear with the passage of the infection to the chronic stage.…”

Section: Introductionmentioning

confidence: 99%

“…These symptoms are transient and spontaneously disappear with the passage of the infection to the chronic stage. However, neurological, pulmonary, cardiac, hepatic, or intestinal complications may appear with or without granulomatous pathology, sometimes with fatal consequences (36,106,168,277). Moderate elevation in serum globulin, serum glutamic oxalacetic transaminase, and serum glutamic pyruvic transaminase levels may occur, indicating liver involvement.…”

Section: Introductionmentioning

confidence: 99%

“…The pronounced hypergammaglobulinemia found in humans (16,26,106) and mice (251) and the occurrence of autoantibodies in the latter (134) (8,14). Proteinuria may be linked to HS disease manifestations (177,232).…”

Section: Introductionmentioning

confidence: 99%

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Immunopathology of Schistosoma mansoni infection

1989

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Schistosomiasis mansoni is a chronic helminthic disease that affects about 100 million people in the tropics. The worms have a life span of 5 to 10 years, and they live in the mesenteric veins of the host. Lightly infected individuals are asymptomatic or manifest mild intestinal symptoms. Heavily infected individuals often develop severe morbidity with hepatosplenomegaly, sometimes with a fatal outcome. Morbidity is attributed to the strong humoral and T-cell-mediated host immune responses developed to a variety of parasite antigens and expressed as tissue inflammations. The immunopathology includes dermatitis, immune complex-mediated kidney disease, and, chiefly, T-cell-mediated granuloma formation and fibrosis around disseminated parasite eggs. This review describes the mechanisms of induction and expression of immunopathology in infected persons and experimental animals. Immunoregulatory mechanisms that modulate the enhanced immune responses and may ameliorate excessive morbidity are discussed.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunopathology of Schistosoma mansoni infection

1989

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“…Manifestations of acute schistosomiasis include fever, anorexia, diarrhea, cachexia, eosinophilia, and leucocytosis. 1 The symptoms have been associated with oviposition by the newly‐matured worm. 2 Granulomas forming around tissue‐trapped eggs are the major cause of pathogenesis for chronic schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

Development of a Molecular Probe to Baboon Interleukin‐10 mRNA for in Situ Hybridization during Experimental Schistosomiasis

Chou

Stich

Marsala

et al. 2000

Annals of the New York Academy of Sciences

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A nucleic acid probe complementary to baboon interleukin 10 (IL‐10) mRNA was developed for in situ hybridization. Highly conserved IL‐10 protein sequences from several mammals were aligned to design oligonucleotide primers flanking a 270‐bp sequence of the target cDNA. RNA was isolated from stimulated peripheral blood mononuclear cells (PBMC). IL‐10 cDNA was reverse‐transcribed from the total PBMC RNA and amplified with the polymerase chain reaction (PCR). Cloning and sequencing of the PCR product confirmed it to be of baboon IL‐10 origin, with 97.8% identity to human and 100% identity to macaque mRNA sequences. The baboon IL‐10 DNA probe hybridized in Southern blots to a 7.9‐Kbp or 8.6‐Kbp band after digestion of genomic baboon DNA with Bam H1 or Eco R1, respectively. Preliminary results with an antisense riboprobe derived from this sequence showed the presence of IL‐10 mRNA in sections of granulomatous tissues.

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Dermatologic Manifestations of Schistosomiasis Mansoni

Torres¹

1976

Arch Dermatol

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Acute Manson's schistosomiasis

Cited by 62 publications

References 21 publications

Immunopathology of Schistosoma mansoni infection

Immunopathology of Schistosoma mansoni infection

Development of a Molecular Probe to Baboon Interleukin‐10 mRNA for in Situ Hybridization during Experimental Schistosomiasis

Dermatologic Manifestations of Schistosomiasis Mansoni

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