Acute Mountain Sickness, Vitamin C, Free Radicals, and HIF-1α

Pattinson, Kyle T.S.; Sutherland, Andrew; Smith, Thomas G.; Dorrington, Keith L.; Wright, Alex

doi:10.1580/1080-6032(2005)16[172:amsvcf]2.0.co;2

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Deficiency of oxygen (hypoxic condition) has numerous detrimental and even life-changing effects on health. Hypoxia may be induced by many factors, including altitude and self-related conditions such as ischemia, atherosclerosis and cancer [ 126 ]. Several cellular mechanisms are triggered and can ameliorate hypoxic conditions, among which extracellular signal-regulated kinase(ERK)-mediated transactivation of the transcription factor and hypoxia-inducible factors (HIF) are believed to participate [ 151 ].…”

Section: Effects Of Hmf On Human Healthmentioning

confidence: 99%

5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health

Shapla

Solayman

Alam

et al. 2018

Chemistry Central Journal

400

224

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An organic compound known as 5-hydroxymethylfurfural (HMF) is formed from reducing sugars in honey and various processed foods in acidic environments when they are heated through the Maillard reaction. In addition to processing, storage conditions affect the formation HMF, and HMF has become a suitable indicator of honey quality. HMF is easily absorbed from food through the gastrointestinal tract and, upon being metabolized into different derivatives, is excreted via urine. In addition to exerting detrimental effects (mutagenic, genotoxic, organotoxic and enzyme inhibitory), HMF, which is converted to a non-excretable, genotoxic compound called 5-sulfoxymethylfurfural, is beneficial to human health by providing antioxidative, anti-allergic, anti-inflammatory, anti-hypoxic, anti-sickling, and anti-hyperuricemic effects. Therefore, HMF is a neo-forming contaminant that draws great attention from scientists. This review compiles updated information regarding HMF formation, detection procedures, mitigation strategies and effects of HMF on honey bees and human health.

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Section: Effects Of Hmf On Human Healthmentioning

confidence: 99%

5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health

Shapla

Solayman

Alam

et al. 2018

Chemistry Central Journal

400

224

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“…Environmental factors such as altitude and selfrelated factors such as atherosclerosis, cancer, and ischemia may initiate hypoxic injury (Semenza 2004;Pattinson et al 2005). Hypoxic injury is becoming a primary threat to the health of humans.…”

Section: Introductionmentioning

confidence: 99%

The protective role of 5-HMF against hypoxic injury

Wu²,

Zhao³

et al. 2011

Cell Stress and Chaperones

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In an attempt to find new types of anti-hypoxic agents from herbs, we identified 5-hydroxymethyl-2-furfural (5-HMF) as a natural agent that fulfills the criterion. 5-HMF, the final product of carbohydrate metabolism, has favorable biological effects such as anti-oxidant activity and inhibiting sickling of red blood cells. The role of 5-HMF in hypoxia, however, is not yet. Our pilot results showed that pretreatment with 5-HMF markedly increased both the survival time and the survival rate of mice under hypoxic stress. The present study was aimed to further investigate the protective role of 5-HMF and the underlying mechanisms in hypoxic injury using ECV304 cells as an in vitro model. ECV304 cells pretreated with or without 5-HMF for 1 h were exposed to hypoxic condition (0.3% O 2 ) for 24 h and then cell apoptosis, necrosis, the changes of mitochondrial membrane potential (MMP) and the expressions of phosphorylation-extracellular signal-regulated kinase (p-ERK) were investigated. Pretreatment with 5-HMF markedly attenuated hypoxia-induced cell necrosis and apoptosis at late stage (p<0.01). Furthermore, pretreatment with 5-HMF rescued both the decline of the MMP and the increase of p-ERK protein under hypoxia. In a word, these results indicated that 5-HMF had protective effects against hypoxic injury in ECV304 cells, and its effects on MMP and p-ERK may be involved in the mechanism.

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