Acute Myeloid Leukemia Accompanied by Multiple Thrombophlebitis.

Tsumita, Yuki; Maekawa, Takafumi; Uchiumi, Hideki; Narahara, Nobuhiro; Tamura, Jun’ichi; Karasawa, Masamitsu; Murakami, Hirokazu; Naruse, Takuji

doi:10.2169/internalmedicine.36.595

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…In patients presenting with thrombosis in the absence of DIC, deficiency of prothrombotic factors was investigated. Tsumita et al reported a case of AML with multiple thrombophlebitis due to hereditary protein C deficiency [4]. Another report of AML associated with DVT as a result of antithrombin III deficiency has also been reported [5].…”

Section: Discussionmentioning

confidence: 99%

“…Protein S is a glycoprotein cofactor for protein C and circulates in both an active (free) form and in an inactive complex with C4b binding protein [3]. Very few studies have measured the levels of proteins C and S in leukemia patients, their contributions to risk of thrombosis, and whether the levels are altered when the patients develop DIC [4][5][6][7][8]. The aim of this study was to evaluate the levels of the above-mentioned proteins in leukemia patients at presentation.…”

Section: Introductionmentioning

confidence: 99%

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Roles of protein C, protein S, and antithrombin III in acute leukemia

et al. 2006

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Protein C, protein S, and antithrombin III were measured in 35 patients with acute leukemia (13 with AML and 22 with ALL). Low levels of proteins C and S were present in 15 (42.9%) and 20 (57.1%) patients, respectively, and 6 patients had low levels of antithrombin (ATIII). Seven patients also had DIC at presentation. There were no significant differences in the levels of protein C, protein S, and ATIII in patients with or without DIC. Twenty patients were available for re-evaluation at the end of induction therapy. The low levels of protein C and ATIII found at diagnosis had risen to normal levels at the end of the induction therapy, while low =levels of protein S remained in 75% of the patients. One patient with low protein C at presentation developed myocardial infarction on day 15, and another patient died of progressive neuropathy. No other thrombotic manifestations were seen. Whether the low protein C, protein S, or antithrombin levels predispose patients with acute leukemia to thrombosis in the absence of DIC is not known. Am.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Roles of protein C, protein S, and antithrombin III in acute leukemia

et al. 2006

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“…Patients with hematological malignancies have the highest risk of venous thrombosis, adjusted for age and sex (adjusted OR 28.0; 95% CI 4.0-199.7) [3]. Venous thrombosis is often accompanied with DIC [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Migrating venous thrombosis in acute leukemia

Musil

Krč²

2010

Blood Coagulation & Fibrinolysis

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“…Parmi les étiologies rapportées à la thrombose chez les patients atteints de LA, on peut citer le déficit constitutionnel en PC comme dans notre observation : le déficit héréditaire en PC avec une histoire familiale de tendance thrombotique au cours d'une LAM avec thrombophlébite multiple décrit par Tsumita et al [8] ; le déficit héréditaire en PC avec ischémie de l'artère iliaque externe droite dans une LAM5 par Kafetzakis et al [5].…”

Section: Discussionunclassified