Acute Myeloid Leukemia Presenting as Obstructive Jaundice

Abstract

A 36-year-old man presented with abdominal pain and jaundice. Ultrasound examination of the abdomen showed dilatation of the intrahepatic bile ducts and a normal common bile duct. No calculi were demonstrated. A computerized tomography scan did not show any masses. A peripheral blood smear was diagnostic of acute myeloid leukemia. After remission-inducing chemotherapy, there was a complete regression of the jaundice, which had not recurred at the 12-month follow-up.

Acute liver failure due to liver parenchymal infiltration with acute myelogenous leukaemia in a patient with myelodysplastic syndrome

“…Liver parenchymal infiltration due to AML is rarely reported in the literature. The majority of cases presented with cholestasis and obstructive jaundice4; however, few case reports have described a transaminitis without evidence of cholestasis 5. Previously reported patients with this diagnosis have been treated with cytarabine and anthracycline at the time of diagnosis but most patients only experience remission for a short period of time 4.…”

Abnormal Hepatic Function and Splenomegaly on the Newly Diagnosed Acute Leukemia Patients

“…19 Goor, Yoav et all, published a paper on acute myeloid leukemia presenting as obstructive jaundice. 20 We strongly believe that the elevated ALP and gamma GGT are due to infiltration of leukemic cells and obstruction of biliary tracts. Our study showed relationship between elevated ALP and GGT with high bone marrow blasts.…”

Acute Myeloid Leukemia Presenting as Obstructive Jaundice Caused by Granulocytic Sarcoma

“…Obstructive jaundice arising from merely leukemic infiltrate of the bile ducts has been rarely reported to show a favorable response to systemic therapy and mandate further local intervention. 10,11 Goor et al reported a patient who presented with obstructive jaundice and a rapid rise in bilirubin level. 11 Prompt chemotherapy without temporary drainage procedures resolved presumptive biliary leukemic infiltration.…”

“…10,11 Goor et al reported a patient who presented with obstructive jaundice and a rapid rise in bilirubin level. 11 Prompt chemotherapy without temporary drainage procedures resolved presumptive biliary leukemic infiltration. Mano et al, in the report on a patient who presented with jaundice in whom computed tomography disclosed thickening of the common bile duct, noted possible institution of chemotherapy after placement of endoscopic nasobiliary drainage.…”