Acute myocardial infarction and ischemic stroke coexistence due to marijuana abuse in an adolescent

Keskin, Muhammed; Hayıroğlu, Mert İlker; Keskin, Ümran; Eren, Mehmet

doi:10.14744/anatoljcardiol.2016.6978

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…68 Cardiac effects include tachycardia and acute myocardial infarction. 69,70 A cardiac fatality was reported in a young adult after smoking SCs. 71 Hematologic abnormalities due to long-acting vitamin K-dependent antagonist contamination of SCs have been reported.…”

Section: Scsmentioning

confidence: 99%

Marijuana and the Pediatric Population

Dharmapuri

Klein

2020

Pediatrics

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Cannabinoids, the psychoactive compounds in marijuana, are one of the most commonly used substances in the United States. In this review, we summarize the impact of marijuana on child and adolescent health and discuss the implications of marijuana use for pediatric practice. We review the changing epidemiology of cannabis use and provide an update on medical use, routes of administration, synthetic marijuana and other novel products, the effect of cannabis on the developing brain, other health and social consequences of use, and issues related to marijuana legalization. EPIDEMIOLOGY Cannabis is one of the most commonly used psychoactive substances in the United States.

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Section: Scsmentioning

confidence: 99%

Marijuana and the Pediatric Population

Dharmapuri

Klein

2020

Pediatrics

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“…In addition, acute myocardial infarction (MI) has been associated with SC use in adolescents and adults 22. A 15-year-old with a 30-month history of SC abuse presented with ST segment elevation MI and stroke 23. Myocardial infarction was also reported in the case of a 39-year-old who presented with left-side chest pain and who subsequently collapsed with ventricular fibrillation 12.…”

Section: Resultsmentioning

confidence: 99%

Review of the many faces of synthetic cannabinoid toxicities

Alipour¹,

Patel

Shabbir

et al. 2019

Mental Health Clinician

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Introduction Synthetic cannabinoids (SCs) are psychoactive substances that are gaining popularity for their availability and lack of detection by standardized drug tests. Although some users may perceive SCs as safer alternatives to marijuana, some SCs are more potent and result in more severe toxicities. Methods A search of the literature was conducted in the PubMed and SciFinder databases. Results in PubMed were limited to human studies, and only articles in English were included. Results Review of the literature illustrates the hazards associated with SC use. A range of severe toxicities affecting numerous systems has been identified, such as arrhythmias, myocardial infarction, sudden cardiac death, psychosis, suicidal ideation, seizures, acute tubular necrosis, and intracranial hemorrhage. Additionally, a recent outbreak of coagulopathies and at least 4 associated deaths due to SCs tainted with brodifacoum have been reported. Discussion Synthetic cannabinoids may be perceived as a safer alternative to marijuana; however, SCs can be more potent at the cannabinoid receptors and in turn have greater toxicities. Limited information is available on the metabolism of SCs; however, cytochrome P450 pathways may be involved, which could result in drug interactions and unpredicted adverse effects. Toxicity with SC use is not just related to its effects, but also to additives that may taint these products and enhance their effects. Health care providers should be aware of the range of toxicities related to SC use, and tainted products such as these agents are not detected on routine drug screens.

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“…The mechanism of this life-threatening situation is unclear and may be multifactorial, from the increased risk of intracardiac thrombus formation due to left ventricular systolic dysfunction, to catecholamine-induced myocardial stunning due to the adrenergic surge associated with cerebral infarction, especially in the insular cortex [6,7]. Moreover, there have been several case reports of CCI attacks in special circumstances, such as aortic dissection, electrical injury, marijuana abuse, or underlying acute myeloid leukemia [8][9][10]. In some cases, a CCI attack may also occur due to atherosclerosis in the cerebral and coronary arteries, respectively [11].…”

Section: Discussionmentioning

confidence: 99%

Which one to do first?: a case report of simultaneous acute ischemic stroke and myocardial infarction

et al. 2021

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Background: Although there are common risk factors for acute ischemic stroke and myocardial infarction, simultaneous onset of both diseases is uncommon. Here, we present a case of acute cerebral infarction with concurrent fatal myocardial infarction. Case Report: A 54-year-old man presented with left hemiparesis, gaze preponderance to the right side, and visual and tactile extinction. Computed tomography angiography showed occlusion of the right middle cerebral artery. ST-elevation myocardial infarction was suspected on electrocardiography. After the injection of intravenous tissue plasminogen activator, thrombectomy was attempted first, and the coronary angiogram was planned after recanalization of the cerebral artery. However, thrombectomy was discontinued because of cardiac arrest. Despite extracorporeal membrane oxygenation and emergency percutaneous coronary intervention, the patient died of multiorgan failure.Conclusion: Double primary acute ischemic stroke and myocardial infarction are rare but may be fatal due to the narrow therapeutic time window for both diseases. Careful consideration of the urgency of cardiac status is essential.

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Acute myocardial infarction and ischemic stroke coexistence due to marijuana abuse in an adolescent

Cited by 11 publications

References 7 publications

Marijuana and the Pediatric Population

Marijuana and the Pediatric Population

Review of the many faces of synthetic cannabinoid toxicities

Which one to do first?: a case report of simultaneous acute ischemic stroke and myocardial infarction

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