Acute Necrotizing Encephalopathy due to Streptococcus pneumoniae: An Uncommon Pathogen in a Devastating Disease

Huber, Jody N; Berg, Aaron; Bula-Rudas, Fernando

doi:10.1016/j.pediatrneurol.2020.03.002

Cited by 2 publications

(1 citation statement)

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“…According to the Japanese epidemiological survey, bacterial infections including AFGN account for 3–4% of MERS cases ( Hoshino et al, 2012 ). By contrast, antecedent bacterial infections are very rare in cases of AESD and ANE ( Yamaguchi et al, 2018 ; Huber et al, 2020 ).…”

Section: Infectious Agentsmentioning

confidence: 99%

Genetic and environmental risk factors of acute infection-triggered encephalopathy

et al. 2023

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Acute encephalopathy is a constellation of syndromes in which immune response, metabolism and neuronal excitation are affected in a variable fashion. Most of the syndromes are complex disorders, caused or aggravated by multiple, genetic and environmental risk factors. Environmental factors include pathogenic microorganisms of the antecedent infection such as influenza virus, human herpesvirus-6 and enterohemorrhagic Escherichia coli, and drugs such as non-steroidal anti-inflammatory drugs, valproate and theophylline. Genetic factors include mutations such as rare variants of the SCN1A and RANBP2 genes, and polymorphisms such as thermolabile CPT2 variants and HLA genotypes. By altering immune response, metabolism or neuronal excitation, these factors complicate the pathologic process. On the other hand, some of them could provide promising targets to prevent or treat acute encephalopathy.

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Section: Infectious Agentsmentioning

confidence: 99%