Acute nephrotoxicity an unusual side effect or adverse toxicity of Captagon

Abstract

medical history and revealed no prior kidney diseases. On physical examination, his blood pressure was 162/93mmHg, heart rate was 96beats per minute, respiratory rate was 24. He had significant bilateral lower limbs edema. Abdominal examination showed tenderness over his costo vertebral angles bilaterally. Initial complete blood count (CBC) showed hemoglobin 11grams/ dL, total leukocyte count of 9×10 9 /L and platelet count of 460000/ µL. No schistocytes were found on peripheral blood smear. A blood chemistry panel showed urea nitrogen 27mg/dL (8-21mg/ dL), creatinine 1.1mg/dL (0.8-1.3mg/dL), sodium 136mmol/L (135-145mmol/L), potassium 4.2mmol/L (3.5-5mmol/L), calcium 8.1mg/dL (8.5-10.2mg/dL), glucose 93mg/ dL (65-110mg/dL), LDH 240 U/L (120-220U/L), albumin 3.0g/dL (3.5-5.0g/dL), and total protein 3.2g/dL (5.0-9.0g/dL), HCO 3 20mEq/L (22-29mEq/L). Liver function test was normal. Urinalysis revealed protein (+), with increased red blood cells, no eosinophiluria. Serologic test results for anti-nuclear antibody, anti-double-stranded DNA antibody, rheumatoid factor, cryoglobulinemia, hepatitis B and C, and ANCA were negative. Serum C3 and C4 levels were normal. Chest X-ray showed moderate amount of bilateral pleural effusion. Non-enhanced computed tomography (CT) scan for the abdomen was done to rule out nephrolithiasis as a cause of his presentation, the scan did not reveal any kidney stone or hydronephrosis. Kidney size was normal.