“…In both neuropathology and neuroimaging, it is uncertain whether white matter changes are an intrinsic component of schizophrenia or are the consequence of neuroleptic treatment, social deprivation, or other epiphenomena related to suffering from a chronic psychiatric disorder. A number of studies have suggested that the DTI abnormalities in schizophrenia are confounded by multiple factors, including the duration of illness and treatment with antipsychotic medications (Konopaske et al, 2006(Konopaske et al, , 2008, age (Kochunov et al, 2013a(Kochunov et al, , 2013bGiezendanner et al, 2013;Mandl et al, 2013), sex of the subjects (Savadjiev et al, 2014), and even heavy cigarette smoking (Cullen et al, 2012;Kochunov et al, 2013aKochunov et al, , 2013b.…”