Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat

Peles, Shachar; Miranda, Adrian; Shaker, Reza; Sengupta, Jyoti N.

doi:10.1113/jphysiol.2004.069070

Cited by 44 publications

(30 citation statements)

References 45 publications

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“…At least two independent lines of evidence suggest that such enhanced responsiveness affects different inputs to the same second-order neurons (heterosynaptic facilitation). 1) Direct recording from spinal neurons showed increased responses to somatic stimulation of the site of convergence in animal models of visceral hypersensitivity (45,51). 2) Using paradigms that induce long-term potentiation in the spinal cord, Klein et al (26) showed perceptual changes in humans that support the importance of heterosynaptic facilitation as a mechanism of central sensitization.…”

Section: Discussionmentioning

confidence: 97%

“…But this cross talk goes beyond the two neighboring pelvic organs. Experimentally induced cystitis decreases thresholds to stimulation of the hind paw (viscero-somatic sensitization), and inflammation in the lower extremities causes enhanced responses to colorectal distension (somato-visceral sensitization) (7,36,45). On the basis of these results, we hypothesized that sensitization of colon afferents during inflammation will affect convergent afferent pathways from somatic and visceral structures.…”

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confidence: 93%

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Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways

Lamb

Zhong²,

Gebhart³

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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Chronic pain syndromes affecting different organs often coexist. We hypothesized that sensitization of one afferent pathway may affect converging input from other areas of the body. We induced colitis in mice with 2,4,6-trinitrobenzenesulfonic acid (TNBS); control animals were treated with equal volumes of vehicle (50% ethanol) only. Visceromotor responses to graded colorectal distension, cystometrograms, and response thresholds to mechanical and thermal stimulation of both hind paws were determined on days 7 and 14. Inflammation of colon and bladder was assessed with validated histological markers and scores. TNBS caused significant colitis on day 7 that resolved by day 14; there was no evidence of bladder inflammation. There was a significant hypersensitivity to colorectal distension on day 7, which returned to normal on day 14. This was associated with bladder overactivity, as demonstrated by early onset of micturition and more frequent micturition on day 7 after TNBS administration. Colitis also significantly altered responses to mechanical and thermal stimulation of both hind paws on day 7 but not day 14. We conclude that cross talk between afferent visceral and somatic pathways may contribute to the coexistence of pain syndromes.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 93%

Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways

Lamb

Zhong²,

Gebhart³

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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show abstract

“…4,5 Such findings provide an anatomic basis for how pelvic muscle dysfunction might also result in generalized pelvic pain symptoms, via dorsal horn integration of afferent input. [6][7][8][9] Conversely, extinction of somatic neuroinflammatory triggers may normalize central pain sensitivity, and may explain results from a recent study, where pelvic floor massage alone reduced irritative bladder symptoms in painful bladder syndrome (PBS) patients. 10 Thus, a clear need exists to formally characterize pelvic floor pain dysfunction among both somatic and visceral pelvic pain syndromes.…”

mentioning

confidence: 87%

Vaginal Pressure-Pain Thresholds: Initial Validation and Reliability Assessment in Healthy Women

Tu¹,

Fitzgerald

Kuiken

et al. 2008

The Clinical Journal of Pain

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“…UES contractility, after occurrence, is prolonged in arousal vs. nonarousals. multiple afferent-efferent systems are integrated by virtue of brain stem viscerosomatic convergence phenomena (28,35) resulting in aerodigestive defensive reflexes that maintain aerodigestive safety.…”

Section: Discussionmentioning

confidence: 99%

Esophageal sensation in premature human neonates: temporal relationships and implications of aerodigestive reflexes and electrocortical arousals

Jadcherla

Parks

Peng

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

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Jadcherla SR, Parks VN, Peng J, Dzodzomenyo S, Fernandez S, Shaker R, Splaingard M. Esophageal sensation in premature human neonates: temporal relationships and implications of aerodigestive reflexes and electrocortical arousals. Am J Physiol Gastrointest Liver Physiol 302: G134 -G144, 2012. First published August 18, 2011 doi:10.1152/ajpgi.00067.2011 as an effect of visceral provocation or of its temporal relationships with aerodigestive reflexes in premature neonates is not known. We tested the hypothesis that esophageal provocation results in both esophageal reflex responses and ECAs during sleep and that ECAs are dependent on the frequency characteristics of esophageal neuromotor responses. We defined the spatiotemporal relationship of ECAs in relation to 1) spontaneous pharyngoesophageal swallow sequences and gastroesophageal reflux (GER) events and 2) sensory-motor characteristics of esophageal reflexes. Sixteen healthy premature neonates born at 27.9 Ϯ 3.4 wk were tested at 36.8 Ϯ 1.9 wk postmenstrual age. Ninety-five midesophageal and 31 sham stimuli were given in sleep during concurrent manometry and videopolysomnography. With stimulus onset as reference point, we scored the response latency, frequency occurrence and duration of arousals, peristaltic reflex, and upper esophageal sphincter contractile reflex (UESCR). Changes in polysomnography-respiratory patterns and esophageal sensory-motor parameters were scored by blinded observers. Significantly (for each characteristic listed, P Ͻ 0.05), swallow sequences were associated with arousals and sleep state changes, and arousals were associated with incomplete peristalsis, response delays to lower esophageal sphincter relaxation, and prolonged esophageal clearance. GER events (73.5%) provoked arousals, and arousals were associated with response delays to peristaltic reflexes or clearance, sleep state modification, and prolonged respiratory arousal. Midesophageal stimuli (54%) provoked arousals and were associated with increased frequency, prolonged latency, prolonged response duration of peristaltic reflexes and UESCR, and increased frequency of sleep state changes and respiratory arousals. In human neonates, ECAs are provoked upon esophageal stimulation; the sensory-motor characteristics of esophageal reflexes are distinct when accompanied by arousals. Aerodigestive homeostasis is defended by multiple tiers of aerodigestive safety mechanisms, and when esophageal reflexes are delayed, cortical hypervigilance (ECAs) occurs.

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Acute nociceptive somatic stimulus sensitizes neurones in the spinal cord to colonic distension in the rat

Cited by 44 publications

References 45 publications

Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways

Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways

Vaginal Pressure-Pain Thresholds: Initial Validation and Reliability Assessment in Healthy Women

Esophageal sensation in premature human neonates: temporal relationships and implications of aerodigestive reflexes and electrocortical arousals

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