Acute oedematous dermatomyositis

Severe subcutaneous generalized edema in a patient with dermatomyositis

“…[1][2][3][4][5][6][7][8] Adult males are more frequently subjected to this a b condition than adult females, in spite of the female predominance in adult patients with DM/PM. [1][2][3][4][5][6][7][8] Cases of juvenile DM with anasarca were also reported.…”

“…To the best of our knowledge, this is the 12th reported case of generalized edema due to DM/PM, and the sixth in patients with DM reported in the literature. [1][2][3][4][5][6][7][8] The etiology and prognosis of DM/PM with generalized edema are still unknown. We report a 78-year-old woman who presented with severe subcutaneous edema in her upper and lower extremities as an initial clinical manifestation of DM.…”

Lymphatic blockage and severe edema in dermatomyositis: lessons from this case and others

“…Edema was noted in either upper or lower extremities. In eight out of fifteen cases, the edema resolved after administration of steroids only [3,[5][6][7][8][9] . However, five out of the fifteen cases improved only after the addition of more aggressive treatment [2,4] , such as IVIG, possibly suggesting the roles of increased capillary permeability in the pathogenesis of subcutaneous edema.…”

“…Dermatomyositis (DM) is a rare systemic inflammatory disorder [1] , and generalized edema of extremities is under-represented in the DM literature [2][3][4][5][6][7][8][9][10] . Thus far, there have only been thirteen case reports of DM with severe generalized edema (see Table).…”

“…Thus far, there have only been thirteen case reports of DM with severe generalized edema (see Table). Various imaging modalities have been used in the past to delineate the underlying cause of the edema [2][3][4][5][6][7][8][9][10] . Here we have described a case of dermatomyositis and severe edema with abnormal lymphoscintigraphy.…”