Acute on chronic respiratory failure in interstitial pneumonias

Westhoff, M.

doi:10.1007/s00063-014-0388-6

Cited by 5 publications

(1 citation statement)

References 46 publications

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“…Only patients with completely available clinicopathological data, such as gender, age, smoking status, relevant medication, time of ILD diagnosis, comorbidities, high-resolution CT scans and outcome data, were included. Patients included in this study predominantly underwent surgical lung biopsy; patients unable to undergo surgical lung biopsy due to functional limitations [18], comorbidity or patient decline and having transbronchial biopsy with sufficient material for histopathological evaluation were also eligible.…”

Section: Methodsmentioning

confidence: 99%

Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies

Kreuter¹,

Kirsten²,

Bahmer³

et al. 2015

Respiration

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Background: Increasing evidence suggests a role of gastro-oesophageal reflux (GER) in idiopathic pulmonary fibrosis (IPF) pathogenesis. Recently, an association between serum Helicobacter pylori (HP) antibody positivity and more severe disease was described, but HP has not been directly analysed in lung tissue so far. Objective: To investigate the presence of HP in the lung tissue of IPF patients. Methods: Two tertiary interstitial lung disease care centre databases were screened for available lung biopsy material from IPF patients. Clinical and radiological data, including presence of GER and antiacid medication, were evaluated. HP-specific PCR was carried out on the IPF lung biopsy specimens. Results: A total of 39 IPF patients were included, of whom 85% were male. The patients' median age was 66 years, their vital capacity was 79% predicted, and their diffusing capacity for carbon monoxide was 53% predicted. In all, 82% of the lung biopsies were surgical and 18% transbronchial. Comorbidities were GER disease in 23% (n = 9), sleep apnoea in 13% (n = 5) and hiatal hernia in 38% of the cases (n = 15). Proton pump inhibitors were prescribed at the time of biopsy in 21% of the cases (n = 9). After a median follow-up of 25 months (range 6-69), there were 1 death, 1 lung transplantation and 8 acute exacerbations without relevant differences between the GER and non-GER subgroups. HP DNA was not detected in any of the lung tissue samples. Conclusion: The fact that no HP DNA was detected in the lung tissues calls into question the proposed relevance of HP to the direct pathogenesis of IPF.

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Section: Methodsmentioning

confidence: 99%