Acute otitis media in the children: etiology and the problems of antibacterial therapy

Протасова, И. Н.; Peryanova, Olga V.; Podgrushnaya, T S

doi:10.17116/otorino201782284-89

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…According to the gender, our study demonstrated that the incidence of CSOM in male were more than female as (53.7%) and (46.3%), respectively, table ( 2). found the opposite, they reported that the infection percentage in female were more than male.…”

Section: Resultsmentioning

confidence: 57%

“…Otitis media (OM) is an infection of the middle ear that affects patients, children, and outpatients who use antibiotics randomly (Meherali et al, 2019). OM can be connected with consequences including hearing loss, recurrent acute otitis media, persistence of middle ear effusion, mastoiditis, and chronic otitis media (Protasova et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of Mixed Lactobacilli in Combination with Antibiotics Against Bacterial Pathogens Causing Chronic Suppurative Otitis Media

Jassim¹,

Algburi²

2022

PJMHS

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This study aimed to determine the antimicrobial activity of CFS of the selected lactobacilli, alone and in combination with antibiotics against pathogenic bacteria isolated from patients with chronic otitis media. In addition, we investigated the ability of tested lactobacilli (a mixed of Lactobacillus acidophilus and Lactobacillus plantarum) to co-aggregate with the isolated pathogens.. One hundred sixty-two ear swab were collected from patients had otitis media with chronic discharging . These patients attended to the ENT department in the medical consultation clinic at Baquba Teaching Hospital and to private doctors’ clinics. Ear swabs were taken from both sexes, male and female starting from September to the end of December, 2021. The isolates were identified based on their morphological features of the colonies and some biochemical tests. The final identification and antibiotics susceptibility of bacterial isolates was confirmed by VITEK2 compact system. The results showed that 113 samples were positive for bacterial culture, while 30 samples were negative growth, mostly identified as fungi. A total of 113 bacterial species isolated from 162 otitis media samples were: Pseudomonas aeruginosa, Staphylococcus aureus, Proteus mirabilis, and Klebsiella pneumonia. The highest predominant bacterial agents were P. aeruginosa 52 (32%), S. aureus 40 (24.7%), followed by P. mirabilis 14 (8.64%), and K. pneumoniae 7 (4.32%). The obtained results showed that the highest rate of infection was identified in male rather than in female. In antibiotic susceptibility testing, 16 types of antibiotics was evaluated against four bacterial species using VITEK2 system. In addition, disk diffusion assay was utilized in order to perform antimicrobial combinations. The susceptibility of bacterial species were various among these antibiotics. It was noticed that ciprofloxacin was the most effective antibiotic against all the isolated bacteria with the lowest MIC in comparison to the other antibiotics. We evaluated the effect of ciprofloxacin alone and in combination with the cell-free supernatants (CFSs) of mixed lactobacilli against the four isolates using disk diffusion assay. Our results showed that the CFS produced by the mixed lactobacilli have a significant inhibitory effect on the growth of bacterial pathogens. Moreover, CFS in combination with ciprofloxacin was more effective against pathogenic isolates than using ciprofloxacin alone. Co-aggregation of the selected mixed lactobacilli strains with the four bacterial isolates were evaluated in order to investigate the competitive activity of the tested lactobacilli with the isolated pathogens. Keywords: Otitis media, Mixed lactobacilli, Cell Free Supernatant, Co-aggregation, Antimicrobial combinations

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Section: Resultsmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Mixed Lactobacilli in Combination with Antibiotics Against Bacterial Pathogens Causing Chronic Suppurative Otitis Media

Jassim¹,

Algburi²

2022

PJMHS

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“…It can be caused by either bacteria, such as Streptococcus pneumoniae and Haemophilus influenza , or by viruses like respiratory syncytial virus (RSV), coronaviruses, influenza viruses, and adenoviruses. 6,7 Complications such as mastoiditis and cholesteatoma, meningitis, or other intracranial complications may occur but are rare. 8 Because OM is an infectious disease, the policy and environmental efforts aimed at preventing the COVID-19 pandemic that can reduce viral or bacterial spread may affect OM prevalence.…”

Section: Introductionmentioning

confidence: 99%

Changes in Otitis Media During COVID-19

Cho,

Lee,

Ryu

et al. 2024

Ann Otol Rhinol Laryngol

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Objectives: During the COVID-19 pandemic, various non-pharmaceutical interventions such as individual hygiene practices like hand washing, social distancing, and mandates for the use of masks in public spaces were implemented to reduce the spread of the disease. Otitis media (OM) is a common infectious disease. How the changed environment due to the COVID-19 pandemic has influenced the prevalence of infectious diseases like OM is not known. This study aimed to investigate how OM prevalence and trends changed during COVID-19 in Korea. Methods: OM patient data from 2017 to 2021 were extracted from the Health Insurance Review and Assessment Service database. Patients diagnosed with disease code H66 (suppurative and unspecified otitis media) were selected for analysis. Data on OM prevalence, gender, region, medical institution, and number of ventilating-tube prescriptions were analyzed. All age groups were included, and ages were categorized into 5-year ranges Results: The number of patients diagnosed with the OM disease code decreased continuously from 2017 to 2021 (1 598 205, 1 560 178, 1 520 948, 983 701, and 734 901). The average OM prevalence per 1000 persons decreased by 45.0% from 30.2 in 2017 to 2019 to 16.6 in 2020 to 2021. The change of OM prevalence was greater for the 0 to 5 age group than other age groups. The decrease in average prevalence per 1000 persons was greatest in the 0 to 5 age group (48.6% decrease from 358.2 in 2017-2019 to 184.1 in 2020-2021). The impact of environmental changes on ventilation-tube insertion was smaller than on OM prevalence. The average number of ventilating-tube insertions decreased by 28.1% from 27 311 in 2017 to 2019 to 19 650 in 2020 to 2021. Conclusions: OM prevalence decreased by 45.0%, and the number of ventilating-tube insertions decreased by 28.1% in Korea during COVID-19.

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“…Otitis media (OM) is an infection of the middle ear that affects patients, adult and children, who abuse and overuse of antibiotics [1]. The complications of OM infection may lead to hearing loss, recurrent acute otitis media, persistence of middle ear effusion, mastoiditis, and chronic otitis media [2]. The acute cases of otitis media (AOM) is characterized by the accumulation of fluids in the middle ear and the presence of symptoms of the middle ear infection [3].…”

Section: Introductionmentioning

confidence: 99%

“…P-ISSN:Figure 1: Antibacterial activity of ciprofloxacin against bacterial isolatesRegarding the CFS of mixed lactobacilli, it was found to be 25% against P. mirabilis which inhibited 91.4%, while was 50% against k. pneumoniae, P. aeruginosa, and S. aureus caused growth inhibition 93.3%, 90.5%, and 90.5%, respectively, figure(2).P-ISSN:…”

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confidence: 99%

Antibacterial and Antibiofilm Activity of the Mixed Lactobacilli Against the Most Bacterial Etiology of Otitis Media

Jassim¹

2023

acad. sci. j.

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The present study aimed to investigate the anti-biofilm activity of Cell Free Supernatant (CFS) and Biosurfactant (BS) of mixed lactobacilli (L. acidophilus and L. plantarum) against biofilm formation by bacterial pathogens isolated from chronic otitis media. In addition, the antimicrobial potential of ciprofloxacin in combination with CFS of lactobacilli species was evaluated againt the tested pathogens. The automated identification of bacterial isolates was peroformed by VITEK2 compact system their antibiotics susceptibility was evaluated using disc diffusion method. The minimum inhibitory concentrations (MIC) of the mixed lactobacilli CFS and ciprofloxacin were determine against the bacterial isolates using broth micro-dilution assay. Anti-biofilm activities of CFS and bio-surfactant of the mixed lactobacilli were evaluated against the biofilm-associated bacterial isolates. The minimum biofilm inhibitory concentrations (MBIC50) were determined. In the current study, one hundred sixty-two ear swab were collected from had otitis media cases with chronic discharging. These patients attended to the ENT department in the medical consultation clinic at Baquba Teaching Hospital and to private doctors' clinics. Ear swabs were taken from both genders during September 2021 to the end of December. The most bacterial species isolated from otitis media samples were Pseudomonas aeruginosa and Staphylococcus aureus. Ciprofloxacin was an effective antibiotic against the tested pathogenic bacteria. The mixed lactobacilli CFS showed an inhibitory effect at MIC90 (25%) against P. mirabilis but (50%) against P. aeruginosa, S.aureus, and K.

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Acute otitis media in the children: etiology and the problems of antibacterial therapy

Cited by 8 publications

References 38 publications

Antimicrobial Activity of Mixed Lactobacilli in Combination with Antibiotics Against Bacterial Pathogens Causing Chronic Suppurative Otitis Media

Antimicrobial Activity of Mixed Lactobacilli in Combination with Antibiotics Against Bacterial Pathogens Causing Chronic Suppurative Otitis Media

Changes in Otitis Media During COVID-19

Antibacterial and Antibiofilm Activity of the Mixed Lactobacilli Against the Most Bacterial Etiology of Otitis Media

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