Acute postnatal exposure to the pentaBDE commercial mixture DE-71 at 5 or 15mg/kg/day does not produce learning or attention deficits in rats

Driscoll, Lori; Kaplan, Joshua S.; Bucuvalas, Eleni; Allen, H. M.; Kraut, J.; Fitzpatrick, J. Lawrence

doi:10.1016/j.ntt.2011.10.002

Cited by 10 publications

(16 citation statements)

References 56 publications

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“…Some animal studies have also suggested that PBDEs may cause cognitive impairment, specifically related to learning, memory, and visual discrimination, while others have shown no effect on learning and attention . Small epidemiologic studies have recently reported on cognitive effects of early‐life exposures to PBDEs, also with inconsistent results.…”

Section: Commentmentioning

confidence: 99%

“…34 Some animal studies have also suggested that PBDEs may cause cognitive impairment, specifically related to learning, memory, and visual discrimination, 34,36,37 while others have shown no effect on learning and attention. 36,38 Small epidemiologic studies have recently reported on cognitive effects of early-life exposures to PBDEs, also with inconsistent results. Cord blood PBDEs have been positively associated with cognitive function in 8-12 month infants (BDE-99, Σ BDEs) (n = 36), 17 but they have not been associated with cognitive function at age 4 (BDE-47) (n = 88).…”

Section: Commentmentioning

confidence: 99%

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Brominated Flame Retardants in Breast Milk and Behavioural and Cognitive Development at 36 Months

Adgent

Hoffman

Goldman³

et al. 2013

Paediatric Perinatal Epid

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Background Polybrominated diphenyl ethers (PBDEs) are persistent flame retardants found in the environment, in household dust, and in humans. Breast feeding is a prominent route of exposure in infancy. PBDEs adversely affect neurodevelopment in animals. Here, we estimate associations between PBDEs in breast milk and behavior and cognitive skills in children at 36 months of age. Methods We prospectively studied 304 mothers and their children. We measured PBDEs in breast milk collected at 3 months postpartum. At 36 months, we measured child behavior with the parent-rated Behavioral Assessment System for Children 2 (n = 192), and cognitive skills with the Mullen Scales of Early Learning (n = 184). We analysed data with robust regression. Results We detected BDE-28, −47, −99, −100, and −153 in >70% of milk samples. For each congener, the highest quartile of breast milk PBDE concentration, versus the lowest, was associated with more anxious behavior, after confounder adjustment. Select congeners were associated with increased withdrawal (BDE-28) and improved activity of daily living skills (BDE-153). Cognitive skills tended to be positively associated with PBDEs, especially language and fine motor skills. However, most estimates were imprecise. Conclusions Here, lactational PBDE exposure was modestly and imprecisely associated with anxiety and withdrawal, but was also associated with improved adaptive and cognitive skills. Positive factors associated with breast feeding may have mitigated some of the hypothesized adverse neurodevelopmental outcomes associated with PBDEs. Further research is needed to inform our understanding of PBDE neurotoxicity and how sources of exposure might confound neurodevelopmental studies.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Brominated Flame Retardants in Breast Milk and Behavioural and Cognitive Development at 36 Months

Adgent

Hoffman

Goldman³

et al. 2013

Paediatric Perinatal Epid

View full text Add to dashboard Cite

show abstract

“…Acute postnatal exposure to mixture DE-71, consisting of BDE-47, −99, −100, −153, and −154, did not produce effects on attention or impulse control in rats (Driscoll et al, 2012; Dufault et al, 2005). However, rats who received chronic postnatal doses of DE-71, which is more similar to human exposure scenarios, had significant impairment in sustained attention and increased impulsivity (Driscoll et al, 2009).…”

Section: Discussionmentioning

confidence: 86%

Prenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children

Vuong

Yolton

Poston

et al. 2017

Neurotoxicology and Teratology

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Exposure to polybrominated diphenyl ethers (PBDEs) during fetal development may be associated with deficits in attention and impulse control. However, studies examining postnatal PBDE exposures and inattention and impulsivity have been inconsistent. Using data from 214 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort with enrollment from 2003–2006 in the Greater Cincinnati Area, we investigated the relationship of both prenatal and postnatal PBDE exposures with attention and impulse control. Serum PBDEs were measured at 16±3 weeks of gestation and during childhood at 1, 2, 3, 5, and 8 years. We assessed children’s attention and impulse control using the Conners’ Continuous Performance Test-Second Edition (CPT-II) at 8 years. We used multiple informant models to estimate associations of repeated PBDE measures with inattention and impulsivity. There was a pattern of associations between PBDEs and poorer performance on CPT-II measures of attention. For BDE-153, adverse associations extended to exposures at preschool and kindergarten ages; ten-fold increases in exposure were associated with higher omission errors (BDE-153 at 3 years: β=4.0 [95% CI: −2.4, 10.4]; at 5 years: β=4.6 [95% CI: −2.8, 12.0]; at 8 years: β=4.1 [95% CI: −3.4, 11.5]). Longer hit reaction times, indicated by the exponential part of the hit reaction curve, were also observed with 10-fold increases in BDE-153 during the prenatal period and throughout childhood (Prenatal: β=15.0 milliseconds (ms) [95% CI: −15.8, 45.8]; 5 years: β=20.6 ms [95% CI: −20.8, 61.9]; 8 years: β=28.6 ms [95% CI: −12.1, 69.4]). Significant impairment in discriminability, as indicated by detectability (d′), between targets and non-targets was also noted with 5 and 8-year PBDE concentrations. Associations between PBDEs and inattention significantly differed by child sex, with males performing more poorly than females with regard to omission errors and measures of reaction times. Collectively, these results do not strongly support that PBDEs are associated with poorer impulse and attention control among 8 year old children. However, there may be a possible relationship between prenatal and concurrent PBDEs and inattention, which requires additional research.

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“…Although PBDEs are globally dispersed (Law et al, 2008), human and environmental levels of these compounds are approximately one to two orders of magnitude higher in North America than in Europe and Asia (Costa and Giordano, 2007;Frederiksen et al, 2009). Although the lower brominated DE71 mixture is no longer produced, the congener profile of PBDE found in samples of human blood, breast milk, and fatty tissue closely matches that of DE71, with the most heavily represented congeners being the BDE-47, BDE-99, BDE-100, and BDE-153 (Schecter et al, 2007;Driscoll et al, 2012).…”

mentioning

confidence: 99%

“…PBDE are lipophilic, which enables these chemicals to bioaccumulate (lower brominated PBDEs with 1-5 Br atoms bioaccumulate more efficiently) and biomagnify (Aleska et al, 2012). Therefore, it is important to determine the adverse health effects of these chemicals and the levels at which such effects appear (Dunnick et al, 2012;Driscoll et al, 2012;Nash et al 2013;Cowens et al, 2015).…”

mentioning

confidence: 99%

Developmental neurotoxicity of polybrominated diphenyl ethers mixture de71 in Sprague-Dawley rats

Gill

Hou

et al. 2016

Journal of Toxicology and Environmental Health, Part A

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Polybrominated diphenyl ethers (PBDE) are a class of brominated flame retardants that are recognized as global environmental contaminants and a potential adverse health risk. The objective of this study was to evaluate the developmental impacts on rat Sprague-Dawley (SD) pups at postnatal day (PND) 11, 21, 50, 105, and 250 after perinatal exposure to a DE71 mixture. These PNDs corresponded to juveniles, young, and mature adults, respectively. The analysis included histopathological, transcriptional evaluation, and Western blots in both hippocampus and midbrain. There were no marked histopathological changes, but significant transcriptional alterations were observed at PND 21 and 250 in midbrain. These changes occurred in a number of the markers of the cholinergic system, including acetylcholinesterase, muscarinic and nicotinic receptors, and structural gene,s including those of neurofilaments, cell adhesion molecules including N-cadherin and CAMKII, and cytokines. The markers were upregulated at least twofold or greater at PND 21. These biomarkers were predominantly altered in males at low dose (0.3 mg/kg), whereas females were affected only at high concentration (30 mg/kg). At PND 250 both males and females showed downregulation of markers in both intermediate- and high-dose groups. Our results support the findings that in utero and lactational exposure to DE71 mixture leads to transcriptional alterations in midbrain of adult SD rats.

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Acute postnatal exposure to the pentaBDE commercial mixture DE-71 at 5 or 15mg/kg/day does not produce learning or attention deficits in rats

Cited by 10 publications

References 56 publications

Brominated Flame Retardants in Breast Milk and Behavioural and Cognitive Development at 36 Months

Brominated Flame Retardants in Breast Milk and Behavioural and Cognitive Development at 36 Months

Prenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children

Developmental neurotoxicity of polybrominated diphenyl ethers mixture de71 in Sprague-Dawley rats

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