Acute Promyelocytic Leukemia

Abstract

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARα) [...]

A specific esterase and pH logically regulate ESIPT: different kinds of granulocyte sorting

“…This is convenient for the accurate diagnosis and prognostic evaluation of acute myeloblastic leukaemia 6 and acute promyelocytic leukaemia. 7 In particular, if the acid, neutrophil and alkaline granulocytes can be sorted and their corresponding enzymatic activity of NAS-DCE monitored in real-time by differential response signals, then the recognition and diagnosis roles of NAS-DCE would be further enhanced in the field of cell biology and clinical medicine. 8 An increasing amount of data has indicated that the enzymatic activity of NAS-DCE and the environmental medium in the different granulocytes ( i.e.…”