2004
DOI: 10.1016/j.envres.2003.07.007
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Acute pulmonary and hematological effects of two types of particle surrogates are influenced by their elemental composition

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Cited by 39 publications
(23 citation statements)
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References 36 publications
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“…The data presented in this report demonstrate that PM rapidly stimulates ROS generation in human lung vascular endothelium, resulting in increased p38 MAPK activation, HSP27 phosphorylation, and a marked disruption in EC monolayer integrity and barrier function via cytoskeletal rearrangement. As endothelial cell barrier integrity is key to lung homeostasis and the prevention of environmental toxins from accessing other physiologic systems, this pathway contributes to acute inflammatory lung injury (25) and potentially contributes to PM-induced cardiopulmonary dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…The data presented in this report demonstrate that PM rapidly stimulates ROS generation in human lung vascular endothelium, resulting in increased p38 MAPK activation, HSP27 phosphorylation, and a marked disruption in EC monolayer integrity and barrier function via cytoskeletal rearrangement. As endothelial cell barrier integrity is key to lung homeostasis and the prevention of environmental toxins from accessing other physiologic systems, this pathway contributes to acute inflammatory lung injury (25) and potentially contributes to PM-induced cardiopulmonary dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…The process of nasotropic instillation was performed once a day (at 1:00 and 2:00 p.m.), for 12 weeks with an automatic pipette, with 10 μL of solution in the nostril of the animal. This procedure induces apnea reflex promoting the inhalation of the pollutant [24].…”
Section: Dietmentioning
confidence: 99%
“…According to analysis of certain authors, some pollutants found in the airborne emissions of incinerators could induce toxic effects on the human respiration system (Rowat 1999). Animal models were used to understand acute pulmonary and haematological effects of particles produced by incinerators (Diabate et al 2002;Medeiros et al 2004).…”
Section: Introductionmentioning
confidence: 99%