Acute renal and liver failure due to acute fatty liver of pregnancy-complicated pre-eclampsia

Song, Geun Am; Li, Y; Li, M; Xuan, Rongrong

doi:10.3109/01443615.2012.698333

Cited by 9 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The renal injury in AFLP has been proposed to possibly occur due to microvesicular fat in the kidney as a result of inhibition of beta-oxidation of renal fat (90,91). However, studies have reported that within 6 months of delivery renal injury, even for patients with ARF, has been reversed (88,92,93).…”

Section: Aki and Aflpmentioning

confidence: 99%

Acute Kidney Injury in Pregnancies Complicated With Preeclampsia or HELLP Syndrome

et al. 2020

View full text Add to dashboard Cite

Acute kidney injury that occurs during pregnancy or in the post-partum period (PR-AKI) is a serious obstetric complication with risk of significant associated maternal and fetal morbidity and mortality. Recent data indicates that the incidence of PR-AKI is increasing, although accurate calculation is limited by the lack of a uniform diagnostic criteria that is validated in pregnancy. Hypertensive and thrombotic microangiopathic disorders of pregnancy have been identified as major contributors to the burden of PR-AKI. As is now accepted regarding preeclampsia, HELLP syndrome and atypical hemolytic uremic syndrome, it is believed that PR-AKI may have long-term renal, cardiovascular and neurocognitive consequences that persist beyond the post-partum period. Further research regarding PR-AKI could be advanced by the development of a pregnancy-specific validated definition and classification system; and the establishment of refined animal models that would allow researchers to further elucidate the mechanisms and sequelae of the disorder.

show abstract

Section: Aki and Aflpmentioning

confidence: 99%

Acute Kidney Injury in Pregnancies Complicated With Preeclampsia or HELLP Syndrome

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The treatment effect of simple conventional supportive care is not satisfactory, and blood purification technology can replace liver metabolic functions, thus supporting multiple organ function effectively. [3] The combined use of ALSS treatments plays a crucial role in decreasing the level of serum bilirubin, removing or reducing toxic substances, and improving the internal environment of ALF in liver failure patients. It has been reported that the survival rate of patients was 80%-90 % in the early course of ALF.…”

Section: Discussionmentioning

confidence: 99%

Combined use of non-biological artificial liver treatments for patients with acute liver failure complicated by multiple organ dysfunction syndrome

Yun-hang

et al. 2014

World Journal of Emergency Medicine

View full text Add to dashboard Cite

BACKGROUND: Acute liver failure (ALF) caused by viral and non-viral hepatitis is often accompanied with severe metabolic disorders, the accumulation of toxic substances and continuous release and accumulation of a large number of endogenous toxins and inflammatory mediators. The present study aimed to investigate the effects of various combined non-biological artifi cial liver treatments for patients with acute liver failure (ALF) complicated by multiple organ dysfunction syndrome (MODS). METHODS:Thirty-one patients with mid-or late-stage liver failure complicated by MODS (score 4) were randomly divided into three treatment groups: plasmapheresis (PE) combined with hemoperfusion (HP) and continuous venovenous hemodiafiltration (CVVHDF), PE+CVVHDF, and HP+CVVHDF, respectively. Heart rate (HR) before and after treatment, mean arterial pressure (MAP), respiratory index (PaO 2 /FiO 2 ), hepatic function, platelet count, and blood coagulation were determined. RESULTS:Signifi cant improvement was observed in HR, MAP, PaO 2 /FiO 2 , total bilirubin (TBIL) and alanine aminotransferase (ALT) levels after treatment (P<0.05). TBIL and ALT decreased more signifi cantly after treatment in the PE+CVVHDF and PE+HP+CVVHDF groups (P<0.01). Prothrombin time (PT) and albumin were signifi cantly improved only in the PE+CVVHDF and PE+HP+CVVHDF groups (P<0.05). TBIL decreased more significantly in the PE+HP+CVVHDF group than in the HP+CVVHDF and PE+CVVHDF groups (P<0.05). The survival rate of the patients was 58.1% (18/31), viral survival rate 36.4% (4/11), and non-viral survival rate 70% (14/20). CONCLUSION:Liver function was relatively improved after treatment, but PE+HP+CVVHDF was more efficient for the removal of toxic metabolites, especially bilirubin. The survival rate was signifi cantly higher in the patients with non-viral liver failure than in those with viral liver failure.

show abstract

“…Η συνύπαρξη προεκλαµψίας και νεφρικής ανεπάρκειας σχετίζεται µε σοβαρή µαιευτική αιµορραγία. Μελέτη σε έγκυες µε προεκλαµψία και νεφρική ανεπάρκεια έδειξε µεγάλο ποσοστό των περιστατικών αυτών να επιπλέκεται από σύνδροµο HELLP και πρόωρη αποκόλληση πλακούντα (Drakeley et al, 2002;Song et al, 2012).…”

Section: νεφροί και πρωτεϊνουρίαunclassified

Εκτίμηση Των Επιπέδων Ορού Της Βισφατίνης Στην Υπερτασική Νόσο Της Κύησης

Ζορμπά¹

View full text Add to dashboard Cite

Σκοπός της διατριβής ήταν η διερεύνηση της πιθανής σχέσης μεταξύ των επιπέδων της βισφατίνης του ορού και της προεκλαμψίας. Ο τύπος της μελέτης ήταν ασθενών – μαρτύρων, δεδομένης χρονικής στιγμής και η διεξαγωγή της πραγματοποιήθηκε στην Α’ Μαιευτική – Γυναικολογική Κλινική του ΑΠΘ. Στη μελέτη συμμετείχαν εβδομήντα έξι έγκυες γυναίκες, 38 με προεκλαμψία και 38 με φυσιολογική κύηση. Η αντιστοίχιση των ομάδων έγινε ως προς την ηλικία της μητέρας και την ηλικία κύησης, ενώ ο υπολογισμός του μεγέθους δείγματος έγινε με ανάλυση ισχύος. Οι κύριοι παράμετροι που αξιολογήθηκαν ήταν τα επίπεδα της βισφατίνης, του ουρικού οξέος, της ουρίας, της κρεατινίνης, των τρανσαμινασών και των αιμοπεταλίων, τα οποία συγκρίθηκαν μεταξύ των γυναικών με ή χωρίς προεκλαμψία, ενώ δευτερευόντως οι δύο ομάδες συγκρίθηκαν ως προς την ηλικία κύησης κατά τον τοκετό και το βάρος γέννησης των νεογνών. Παρόμοια χαρακτηριστικά κατά την έναρξη της κύησης μεταξύ των δύο ομάδων ήταν η ηλικία της μητέρας, ο δείκτης μάζας σώματος, ο αριθμός ζώντων τέκνων και ο αριθμός των κυήσεων. Τα επίπεδα της βισφατίνης του ορού ήταν στατιστικά σημαντικά αυξημένα στις γυναίκες με προεκλαμψία σε σχέση με την ομάδα ελέγχου. Μονοπαραγοντική ανάλυση αποκάλυψε ισχυρή γραμμική συσχέτιση των επιπέδων της βισφατίνης με τη συστολική, τη διαστολική και τη μέση αρτηριακή πίεση, καθώς και με τα επίπεδα του ουρικού οξέος. Τέλος, ROC ανάλυση έδειξε ότι τα επίπεδα της βισφατίνης του ορού είναι χρήσιμα για τη διάκριση μεταξύ των προεκλαμπτικών ή μη γυναικών, με περιοχή κάτωθεν της καμπύλης 0,887.

show abstract

Acute renal and liver failure due to acute fatty liver of pregnancy-complicated pre-eclampsia

Cited by 9 publications

References 7 publications

Acute Kidney Injury in Pregnancies Complicated With Preeclampsia or HELLP Syndrome

Acute Kidney Injury in Pregnancies Complicated With Preeclampsia or HELLP Syndrome

Combined use of non-biological artificial liver treatments for patients with acute liver failure complicated by multiple organ dysfunction syndrome

Εκτίμηση Των Επιπέδων Ορού Της Βισφατίνης Στην Υπερτασική Νόσο Της Κύησης

Contact Info

Product

Resources

About