Acute Renal Failure After Topical Application of Carbon Tetrachloride

Perez, Alexander; Courel, M; Sobrado, Jose; Gonzalez, Luis

doi:10.1016/s0140-6736(87)92133-7

Cited by 24 publications

(3 citation statements)

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“…On the other hand, the current results are consistent with other studies demonstrated a relationship between kidney disease and CCl 4 liver toxicity [57–59]. Treating the damaged liver rats with olive oil and N. sativa oil protected the liver and improved the kidney function.…”

Section: Discussionsupporting

confidence: 92%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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BackgroundLiver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants. The present study was designed to compare the probable hepatoprotective activity of olive oil and N. sativa oil on CCl4 induced liver damage in male rats.MethodsForty males of a new model of albino rats (Wistar strain) (175–205 g) were divided into four groups. The 1st Group (G1) was the negative control group, the remaining rats were injected with CCl4 (1 ml/kg body weight) with equal amount of olive oil on the 1st and 4th day of every week for 4 weeks. The 2nd group (G2) was the positive control, the 3rd group (G3) and the fourth group (G4) were treated orally with N. sativa oil and olive oils using stomach tube.ResultsThe positive control group showed an increase in hepatic enzymes, total bilirubin, creatinine, uric acid, lipid peroxide total cholesterol, triglyceride, low density lipoprotein, very low density lipoproteins, interleukin-6, and a decrease in antioxidant enzymes, high density lipoprotein cholesterol, a decrease in total protein and albumin an when compared with negative control group. Histology of the CCl4 treated group revealed inflammation and damage of liver cells. Treating the hepatotoxic rats with olive oil and N. sativa oil showed a significant improvement in all biochemical tests compared with the positive CCl4 control group. In addition, the liver tissues of olive oil treated group showed mild improvement in inflammatory infiltration and in N. sativa oil treated group showed normal hepatocytes with no evidence of inflammation.ConclusionThis study revealed that olive oil and N. sativa oil have a protective effect against CCl4-induced hepatotoxicity in male rats. Nigella sativa oil was more effective than olive oil.

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Section: Discussionsupporting

confidence: 92%

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats

Al‐Seeni

Rabey

Zamzami

et al. 2016

BMC Complement Altern Med

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“…Various studies have been shown that several xenobiotics cause generation of free radicals, which play a major role in initiation of oxidative stress-related diseases. Extensive in vivo studies on rodents have demonstrated that CCl 4 causes injuries to liver,[ 6 ] kidney,[ 7 ] and many organs via generation of electrophilic trichloromethyl (CCl 3 ) and peroxy trichloromethyl (OOCCl 3 ) radicals. [ 32 ] Such reactive free radicals produced from halogenated alkanes by the metabolizing activity of cytochrome P450 2E1 (CYP2E1) was reported to induce hepato-and nephrotoxicity[ 33 ] as they start to initiate lipid peroxidation and protein deterioration.…”

Section: Discussionmentioning

confidence: 99%

“…Liver diseases and nephrotoxicity represent serious health problems. [ 6 7 ] Since synthetic drugs used in treatment of liver and kidney diseases are inadequate or have serious adverse effects, search of safe and readily available natural products or nutraceuticals could be a preferred alternative solution. The high level of polyphenols claimed in AS195 was thus prompted us to extend the medicinal value of this aqueous extract, on the basis of its expected antioxidant power, by evaluating its efficacy in combating chemically-induced hepatorenal injury.…”

Section: Introductionmentioning

confidence: 99%

Hepatorenal protective effect of Antistax^®against chemically-induced toxicity

et al. 2015

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Background:Antioxidant natural products and chemoprevention are considered nowadays as an effective approach against health various disorders and diseases induced by oxidative stress or free radicals.Objective:The aim of this study was to assess the hepato- and nephroprotective activity of a standardized red vine leaf aqueous extract AS195 (Antistax®).Methods:The protective activity of AS195 (100 mg/kg) was investigated on carbon tetrachloride (CCl4)-intoxicated rats in comparison with silymarin. The flavonoid/proanthocyanidin nature of AS195 was identified by phytochemical and nuclear magnetic resonance (NMR) analyses, while its total phenol/proanthocyanidin/flavonoid content and antioxidant activity were determined by Folin-Ciocalteau, vanillin-sulfuric acid, AlCl3, and 2, 2-diphenyl-2-picrylhydrazyl radical scavenging assays, respectively.Results:Relative to the control CCl4 –intoxicated group, pretreatment with AS195 could significantly suppressed the elevated serum levels of alanine aminotransferase, alkaline phosphatase, γ-glutamyl transferase, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides, bilirubin, creatinine, uric acid, and calcium, whereas it significantly increased the diminished serum levels of high-density lipoprotein cholesterol, albumin and total protein. Moreover, AS195 significantly decreased malondialdehyde formation in the tissues of liver and kidney, whereas it significantly elevated and nonprotein sulfhydryl groups, compared with the intoxicated control. The improvement in biochemical parameters by AS195 was obviously observed and further confirmed by restoration of normal histological features in the two organs.Conclusions:The results of the present study revealed the capacity of AS195 to enhance the recovery from xenobiotic-induced hepatorenal toxicity initiated by free radicals.

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