Acute renal failure due to overdose of colloidal bismuth

Akpolat, İlkser; Kahraman, Hüsnü; Arık, Nurol; Akpolat, T.; Kandemir, B.; Cengiz, Kuddusi

doi:10.1093/oxfordjournals.ndt.a027697

Cited by 10 publications

(4 citation statements)

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“…In another case, a 16-year-old girl presented nausea, vomiting, dizziness, and oliguria after having taken 10-15 tablets of tripotassium dicitrato bismuthane one week before hospital admission (Table 1, Entry 6). A renal biopsy also supported the diagnosis of acute tubular necrosis [104].…”

Section: Toxicity After Systemic Inadequate Use Of Bismuth-based Drugsmentioning

confidence: 74%

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

Gonçalves,

Matias,

Salvador

et al. 2024

IJMS

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Bismuth compounds are considered relatively non-toxic, with their low solubility in aqueous solutions (e.g., biological fluids) being the major contributing factor to this property. Bismuth derivatives are widely used for the treatment of peptic ulcers, functional dyspepsia, and chronic gastritis. Moreover, the properties of bismuth compounds have also been extensively explored in two main fields of action: antimicrobial and anticancer. Despite the clinical interest of bismuth-based drugs, several side effects have also been reported. In fact, excessive acute ingestion of bismuth, or abuse for an extended period of time, can lead to toxicity. However, evidence has demonstrated that the discontinuation of these compounds usually reverses their toxic effects. Notwithstanding, the continuously growing use of bismuth products suggests that it is indeed part of our environment and our daily lives, which urges a more in-depth review and investigation into its possible undesired activities. Therefore, this review aims to update the pharmaco-toxicological properties of bismuth compounds. A special focus will be given to in vitro, in vivo, and clinical studies exploring their toxicity.

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Section: Toxicity After Systemic Inadequate Use Of Bismuth-based Drugsmentioning

confidence: 74%

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

Gonçalves,

Matias,

Salvador

et al. 2024

IJMS

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show abstract

“…The associated signs and symptoms to the exposure were several and are described in Table 1 , along with the treatment performed for each case followed by its outcome. Two case reports were manually included due to its relevance for the reviewed subject [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…After renal biopsy, a case report [ 47 ] where 10–15 tablets of tripotassium dicitrato bismuthate was ingested, hematoxylin-eosin staining was performed. Vacuolation, flattening, necrosis, and prominent regeneration in tubular epithelium (mainly proximal tubuli epithelium) with widening of lumens and localized cell detachment was observed.…”

Section: Discussionmentioning

confidence: 99%

Effects of Bismuth Exposure on the Human Kidney—A Systematic Review

et al. 2022

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The effects of bismuth toxicity on the kidney—the main organ responsible for blood filtration—were systematically reviewed. This review was motivated by availability of several sources of bismuth in contact with humans including environmental, medications, dental materials, and cosmetics, potentially leading to kidney filtration of this chemical. No previous studies have systematically reviewed the literature considering this association. A total of 22 studies with a total of 46 individuals met the inclusion criteria, 19 being case reports with only one patient enrolled. The included studies publication dates ranged from 1961 to 2021 and the countries of publication were the United States of America, United Kingdom, Germany, Turkey, Switzerland, and Canada. Bismuth sources affecting the kidneys were uniquely reported as from medical purposes and mostly associated to overdoses with several symptoms, apparently with dose-dependent consequences. Patient history of renal impairment seemed to affect the outcome of the case. Several therapies were conducted following bismuth intoxication, and few studies performed renal biopsies describing its histological findings. It is crucial to reconsider the nephrotoxicity of bismuth compounds, mainly in patients with previous history of renal impairment.

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“…1 Despite the increasing use of bismuth, information regarding excessive intake of this compound that causes toxicity is limited to a few case reports in the literature. [2][3][4][5] We report a case that developed acute kidney failure, tonsillar ulcer and posterior reversible encephalopathy syndrome (PRES) following the intake of 19 grams of bismuth subcitrate.…”

Section: Introductionmentioning

confidence: 99%

Acute Bismuth Intoxication: Acute Renal Failure, Tonsillar Ulceration and Posterior Reversible Encephalopathy Syndrome

Akıncı

Köylü

Yortanlı

et al. 2015

Hong Kong Journal of Emergency Medicine

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Consumption and production of bismuth compounds are increasing, however, little information on the toxic effects and effective methods in removal of bismuth compounds are available. Although bismuth intoxication is currently rare, a careful evaluation should be carried out for possible exposure. We reported a16-year-old female who developed acute kidney failure, tonsillar ulceration and posterior reversible encephalopathy syndrome after an ingestion of 19 grams of bismuth subcitrate for suicidal attempt. (Hong Kong j.emerg.med. 2015;22:121-125)

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Acute renal failure due to overdose of colloidal bismuth

Cited by 10 publications

References 0 publications

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

Effects of Bismuth Exposure on the Human Kidney—A Systematic Review

Acute Bismuth Intoxication: Acute Renal Failure, Tonsillar Ulceration and Posterior Reversible Encephalopathy Syndrome

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