Acute respiratory distress syndrome induction by pulmonary ischemia–reperfusion injury in large animal models

Fard, Nassim; Saffari, Arash; Emami, Golnaz; Hofer, Stefan; Kauczor, Hans‐Ulrich; Mehrabi, Arianeb

doi:10.1016/j.jss.2014.02.034

Cited by 29 publications

(26 citation statements)

References 75 publications

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“…In addition and similar to the results found for the systemic arterial pressure, the pO2/FiO2 ratio showed a decreased ratio compared to normoxia (G2) and the control group (G1). This suggest that under high oxygen concentration the alveolar/ capillary membrane integrity was probably jeopardized [34], which is in accord to other related studies [4,33,35,36]. It is also important to stress out that lung function after transplant can be also improved by a relatively slow increase in both ventilation rate as well as in blood flow during reperfusion [37].…”

Section: Physiological Parameterssupporting

confidence: 79%

“…Relatively high indices of morbidity and mortality usually accompany organ transplantation including lung transplant [1][2][3][4][5]. Ischemia-reperfusion (IR) and its associated injury is a complex phenomenon present in atherosclerosis, trauma, pulmonary embolism, and surgical procedures, such as cardiopulmonary bypass and lung transplant [6].…”

Section: Introductionmentioning

confidence: 99%

“…Ischemia-reperfusion (IR) and its associated injury is a complex phenomenon present in atherosclerosis, trauma, pulmonary embolism, and surgical procedures, such as cardiopulmonary bypass and lung transplant [6]. Reactive oxygen species (ROS) and reactive oxygen species (RNS) overgeneration have been associated with IR injury in different organs [3][4][5][7][8][9][10][11]. Several characteristics and consequences of IR pathological events are present in different organs and tissues, including lung, however ROS overgeneration and the consequent oxidative stress (OS) seem to be a common response always present in such cases [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Focusing lung transplant: physiological and antioxidant responses and effect of allopurinol to ischemia-reperfusion oxidative stress under different inspired oxygen concentrations

Fm¹,

Rj²,

Jj³

et al. 2018

Trends in Transplant

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Section: Physiological Parameterssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Focusing lung transplant: physiological and antioxidant responses and effect of allopurinol to ischemia-reperfusion oxidative stress under different inspired oxygen concentrations

Fm¹,

Rj²,

Jj³

et al. 2018

Trends in Transplant

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“…Serious infection, trauma, shock, intoxication and inhalation of toxic gases are the most common causes of ALI (3). ALI/ARDS is a common critical disease with high morbidity and fatality rates (4). With improvements in medical technology and comprehensive treatment methods, the fatality rate has decreased to a certain extent; however, it remains as high as 30-40% (5).…”

Section: Introductionmentioning

confidence: 99%

Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway

Yan

et al. 2015

International Journal of Molecular Medicine

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Sulforaphane (1-isothiocyanate-4-methyl sulfonyl butane) is a plant extract (obtained from cruciferous vegetables, such as broccoli and cabbage) and is known to exert anticancer, antioxidant and anti-inflammatory effects. It stimulates the generation of human or animal cells, which is beneficial to the body. The aim of the current study was to determine whether sulforaphane protects against lipopolysaccharide (LPS)‑induced acute lung injury (ALI) through its anti-inflammatory effects, and to investigate the signaling pathways involved. For this purpose, male BALB/c mice were treated with sulforaphane (50 mg/kg) and 3 days later, ALI was induced by the administration of LPS (5 mg/kg) and we thus established the model of ALI. Our results revealed that sulforaphane significantly decreased lactate dehydrogenase (LDH) activity (as shown by LDH assay), the wet-to-dry ratio of the lungs and the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) (measured by ELISA), as well as nuclear factor-κB protein expression in mice with LPS-induced ALI. Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI. Lastly, we noted that pre-treatment with sulforaphane activated the nuclear factor-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway in the mice with LPS-induced ALI. These findings demonstrate that sulforaphane exerts protective effects against LPS-induced ALI through the Nrf2/ARE pathway. Thus, sulforaphane may be a potential a candidate for use in the treatment of ALI.

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“…Second, cardiopulmonary bypass is part of the standard surgical treatment protocol, with the same possible influences on reperfusion injury as mentioned in "Cardiopulmonary bypass" section. Third, revascularization results in the diffusion of toxic mediators such as ROS and RNS in both the pulmonary and systemic circulation (55). The lung tissue itself may be protected from ischemic injury during pulmonary thrombo-embolic events when bronchial circulation remains intact.…”

Section: Pulmonary Thromboembolectomymentioning

confidence: 99%

Oxidative and nitrosative stress during pulmonary ischemia-reperfusion injury: from the lab to the OR

Gielis¹,

Beckers²,

Briedé³

et al. 2017

Ann. Transl. Med.

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Oxidative and nitrosative stress are an umbrella term for pathophysiological processes that involve free radical generation during inflammation. In this review, the involvement of reactive oxygen and nitrogen species is evaluated during lung ischemia-reperfusion injury (LIRI) from a surgical point of view. The main biochemical and cellular mechanisms behind free radical generation are discussed, together with surgical procedures that may cause reperfusion injury. Finally, different therapeutic strategies are further explored. A literature search was performed, searching for "lung ischemia reperfusion injury", "reperfusion injury", "large animal model" and different search terms for each section: "surgery", "treatment", "cellular mechanism", or "enzyme". Although reperfusion injury is not an uncommon entity and there is a lot of evidence concerning myocardial ischemia-reperfusion injury, in the lung this phenomenon is less extensively described and studies in large animals are not easy to come by. With increasing number of patients on waiting lists for lung transplant, awareness for this entity should all but rise.

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Acute respiratory distress syndrome induction by pulmonary ischemia–reperfusion injury in large animal models

Cited by 29 publications

References 75 publications

Focusing lung transplant: physiological and antioxidant responses and effect of allopurinol to ischemia-reperfusion oxidative stress under different inspired oxygen concentrations

Focusing lung transplant: physiological and antioxidant responses and effect of allopurinol to ischemia-reperfusion oxidative stress under different inspired oxygen concentrations

Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway

Oxidative and nitrosative stress during pulmonary ischemia-reperfusion injury: from the lab to the OR

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