Acute Side Effects with High Dose Rate Computed Tomography-guided Three-dimensional Brachytherapy in Carcinoma Cervix

Abstract

Objectives: To determine the frequency and grades of acute side effects with three-dimensional brachytherapy in carcinoma cervix using RTOG/EORTC acute radiation morbidity scoring criteria.

Acute Gastrointestinal Complications in the Era of Image Guided High Dose Rate Intracavitary Brachytherapy Following Definitive Chemoradiotherapy for Cervical Cancer

“…In comparable with a recent study (Sadiq, Shahid et al 2020) stratification of grades of acute side effects with respect to age groups revealed that age was not significantly related with severity of acute toxicities, no significant difference was observed in GU, lower GIT and vaginal toxicities with respect to age .…”

“…In comparable with Koji Matsuo et al (Matsuo, Klar et al 2021) as reported that cervical cancer was (48.1%) with grade 3 tumors, (44.7%) with grade 2 neoplasms and associated with older age, higher stage disease, larger tumor size, and lymph node metastasis. Regarding treatment of 30 patients, received concurrent chemoradiotherapy using weekly platinum based chemotherapy with a dose of 45 Gy in 1.8-2 Gy/fraction followed by brachytherapy years with significant difference <0.001 and patients with HTN, 80% of them had grade 2 toxicity with significant difference 0.007, no significant difference for PS, pathology, grade of tumor and stage with a dose of 7GY/4 Fr except two patient received 7GY/2Fr and 7GY/3Fr due to sever toxcity with prescription dose 7GY, that was similar to Sadia Sadiq, Abubaker Shahid et al (Sadiq, Shahid et al 2020) and EMBRACE-I (Pötter, Tanderup et al 2021).…”

“…Regarding acute GIT toxicity in our result; grade 2&0 were the highest being (33.3%) for each, followed by grade 1 (20%) then grade 3 (13.3%), while in Sadia Sadiq et al, Abubaker Shahid et al (Sadiq, Shahid et al 2020) GIT toxicity, Grade 1 was the highest being 30cases (54.5%) followed by Grade-0 toxicity which was observed in 21cases (38.2%) patients. Regarding acute urinary tract toxicity; grade 1 was the highest being (60%), followed by grade 0 (30%) , while in Sadia Sadiq, Abubaker Shahid et al, (Sadiq, Shahid et al 2020) Grade-1 genitourinary toxicity was most Common, 43 cases (78.2%) followed by Grade-II 9 cases (16.2%). Regarding acute vaginal toxicity; grade 2 was the highest being (43.3%), followed by grade 1 (33.3%) while vaginal toxicities of Grade-2 and 3 were commonly seen 29 (52.7%) and 16 (29.1%), respectively (Sadiq, Shahid et al 2020).…”

“…Regarding acute urinary tract toxicity; grade 1 was the highest being (60%), followed by grade 0 (30%) , while in Sadia Sadiq, Abubaker Shahid et al, (Sadiq, Shahid et al 2020) Grade-1 genitourinary toxicity was most Common, 43 cases (78.2%) followed by Grade-II 9 cases (16.2%). Regarding acute vaginal toxicity; grade 2 was the highest being (43.3%), followed by grade 1 (33.3%) while vaginal toxicities of Grade-2 and 3 were commonly seen 29 (52.7%) and 16 (29.1%), respectively (Sadiq, Shahid et al 2020). Patients with GIT grade 0 toxicity all were married (100%), while patients with GIT grade 2 toxicity (80%) of them were married with significant difference 0.015 & patients with grade 0 GIT toxicity was at median age 57 years, grade 2 GIT toxicity was at median age 61 years followed by grade 1 was at age 66.5…”