Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial—Trans-Tasman Radiation Oncology Group

Toxicity after Intensity-Modulated, Image-Guided Radiotherapy for Prostate Cancer

“…These reduced rates of acute toxicity after IMRT and IGRT treatment of PO and WP are of major clinical relevance, not only from a patient's compliance and comfort point of view. Several studies reported a strong association between acute and late toxicity, especially for GI but also for GU toxicity [25,35,51]. This effect of consequential late toxicity was also observed in our patient population, especially for GI but also for GU toxicity.…”

Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy

“…The development of a nontoxic agent that could simply be administered during the RT course to prevent radiationinduced toxicity would be an important therapeutic advance. Multiple studies have been performed to prevent RIAIS and so far most agents had no effective outcome [12][13][14][15][16][17][18][19]. Fig.…”

Reducing radiation-associated toxicity using online image guidance (IGRT) in prostate cancer patients undergoing dose-escalated radiation therapy

“…In addition, acute toxicity is predictive of late rectal and GU side effects. 30 A meta-analysis 21 of randomized trials of doseescalated irradiation reported late grade ≥2 GI and GU toxicity rates of 17-43% and 21-56%, respectively. Although there were more cases of late grade ≥2 GI toxicity after dose escalation, no significant increase in RTOG grade 3 late urinary or rectal morbidity was identified (high-dose RT vs. conventional-dose RT).…”