Acute toxicity, accumulation and excretion of organophosphorous insecticides and their oxidation products in killifish

Tsuda, Toshitaka; Kojima, Mihoko; Harada, Hiroyuki; Nakajima, Atsuko; Aoki, Shigeru

doi:10.1016/s0045-6535(97)00180-x

Cited by 60 publications

(28 citation statements)

References 15 publications

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“…The 96hLC50 values range in tenths to several tens of mg . l -1 (Seikai 1982;Hidaka et al 1984;Keizer et al 1991;O h et al 1991;Keizer et al 1993;Kikuchi et al 1996;Giddings et al 1996;Tsuda et al 1997). In European eel (Anguilla anguilla) the 96hLC50 values range even in hundredths of mg .…”

mentioning

confidence: 99%

The Effect of Diazinon on Haematological Indices of Common Carp (Cyprinus carpio L.)

Svoboda¹,

Lusková²,

Drastichová³

et al. 2001

Acta Vet. Brno

141

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The goal was to assess an effect of diazinon [0,0-diethyl 0-(2-isopropyl-6-methylpyrimidin-4yl) phosphorothioate] on common carp (Cyprinus carpio L.). The effect was assessed based on results of acute toxicity tests and on a comparison of results of haematological examination of a control and an experimental group exposed to Basudin 600 EW pesticide preparation (active substance 600 g.l -1 of diazinon). The acute toxicity test lasting 96 h was performed semistatically on common carp juveniles. Examination of erythrocyte and leukocyte profile was performed on 15 control and 25 experimental specimens of one-to-two-year-old common carp after 96 h of exposure to Basudin 600 EW in concentration of 32.5 mg . l -1 . The 96hLC50 value of Basudin 600 EW for common carp juveniles was 26.7 mg . l -1 . The experimental group of one-to two-year-old common carp showed significantly lower values (p < 0.01) of erythrocyte count (RBC), haemoglobin content (Hb) and haematocrit (PCV) compared to the control group. Values of MCV, MCH and MCHC were comparable in both groups during the study. In contrary, there was a significant decrease in leukocyte count (Leuko) (p < 0.01), as well as in both the relative and absolute lymphocyte count (p < 0.01) and a significant increase in both the relative and absolute count of developmental forms of neutrophile granulocytes: myelocytes (p < 0.01) and metamyelocytes (p < 0.05) in the experimental group. Relative and absolute count of monocytes and both the band-and segmented neutrophile granulocytes was comparable in both groups during the study. The diazinon-based Basudin 600 EW pesticide preparation was classified among harmful substances for fish. Changes in values of both the erythrocyte and leukocyte profile after exposure to diazinon-based preparation may be refered to disruption of haematopoiesis as well as to a decrease on non-specific immunity of the fish.Organophosphorous pesticide, acute toxicity, erythrocyte profile, leukocyte profile

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mentioning

confidence: 99%

The Effect of Diazinon on Haematological Indices of Common Carp (Cyprinus carpio L.)

Svoboda¹,

Lusková²,

Drastichová³

et al. 2001

Acta Vet. Brno

141

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show abstract

“…Four concentrations of 0.1, 1, 5, and 10 TU were tested with each chemical. Based on the previous reports [34,46], the LC 50-48 , which was regarded as 1 TU in this study, was 10, 2.9, and 0.75 mg/L for T, P, and M, respectively.…”

Section: Monitoring Of Medaka Behavior Movementmentioning

confidence: 68%

Persistence Parameter: a Reliable Measurement for Behavioral Responses of Medaka (Oryzias latipes) to Environmental Stress

Yin

Yang

et al. 2015

Environ Model Assess

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Online monitoring systems provided a significant evidence for feasibility of the stepwise behavioral response model in detecting the effects of organophosphorus pesticides on movements of medaka (Oryzias latipes), being able to determine the state of indicator organisms, Bno effect,^"stimulation," Bacclimation,^Badjustment (readjustment),^and Btoxic effect.^Though the stepwise behavioral response model postulated that an organism displays a time-dependent sequence of compensatory stepwise behavioral response during exposure to pollutants above their respective thresholds of resistance, it was still a conceptual model based on tendency only in analysis. In this study, the phenomenon of bacterial persistence was used to interpret the relationship between the stepwise behavioral response model and the environmental stress caused by both exposure time and different treatments. Quantitative measurements of the stepwise behavioral response model led to a simple mathematical description of the threshold switch, which evaluated the effects of environmental stress on behavioral responses to decide the tendency. The adjustment ability correlated to Bpersisters (p)^is very important for test individuals to overcome the Bthresholdf rom the outside environmental stress. The computational modeling results suggested that Bpersister (p),^as described in the general equations of bacterial persistence model in changing environments, illustrated behavior acclimation and adjustment (or readjustment) clearly. Consequently, the persistence parameter, p, was critical in addressing for medaka to be adapted to fluctuating environments under different environmental stress.

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“…3 for diazinon (Allison & Hermanutz, 1977;Goodman et al, 1979;Kanazawa, 1975;1978;1981;1983;Keizer et al, 1991;Nihon Kagaku-busshitsu Anzen-Jyohou Center, 1992;Seguchi & Asaka, 1981;Sancho et al, 1992;Tsuda et al, 1989a;1995;1997b;1997c), Fig. 4 for fenitrothion (De Bruijn, & Hermens, 1991;Escartin & Porte, 1996;Fisher, 1985;Kanazawa, 1975;1981;1983;1987;Lockhart et al, 1983;Miyamoto et al, 1979;Nihon Kagaku-busshitsu AnzenJyohou Center, 1992;Sancho et al, 1994;Takimoto et al, 1984;1987;Tsuda et al, 1989a;1995;1997b;1997c), Fig. 5 for malathion (Tsuda et al, 1989a;1997b) and fenthion (De Bruijn & Hermens, 1991;Tsuda et al, 1992b;1995;1996b;1997c).…”

Section: Bioconcentration Of Pesticides In Fish By Laboratory Experimmentioning

confidence: 99%

“…4 for fenitrothion (De Bruijn, & Hermens, 1991;Escartin & Porte, 1996;Fisher, 1985;Kanazawa, 1975;1981;1983;1987;Lockhart et al, 1983;Miyamoto et al, 1979;Nihon Kagaku-busshitsu AnzenJyohou Center, 1992;Sancho et al, 1994;Takimoto et al, 1984;1987;Tsuda et al, 1989a;1995;1997b;1997c), Fig. 5 for malathion (Tsuda et al, 1989a;1997b) and fenthion (De Bruijn & Hermens, 1991;Tsuda et al, 1992b;1995;1996b;1997c). The average BCF value of each insecticide was 100 (n=12) for diazinon, 170 (n=10) for fenitrothion, 20 (n=2) for malathion and 340 (n=6) for fenthion.…”

Section: Bioconcentration Of Pesticides In Fish By Laboratory Experimmentioning

confidence: 99%

Bioconcentration of Pesticides in Fish from Rivers and Lakes

Tsuda¹

2011

Pesticides - Formulations, Effects, Fate

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Acute toxicity, accumulation and excretion of organophosphorous insecticides and their oxidation products in killifish

Cited by 60 publications

References 15 publications

The Effect of Diazinon on Haematological Indices of Common Carp (Cyprinus carpio L.)

The Effect of Diazinon on Haematological Indices of Common Carp (Cyprinus carpio L.)

Persistence Parameter: a Reliable Measurement for Behavioral Responses of Medaka (Oryzias latipes) to Environmental Stress

Bioconcentration of Pesticides in Fish from Rivers and Lakes

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