Acute toxicity assessment of methanolic extract of Zingiber roseum (Roscoe.) rhizome in swiss albino mice

Amanat, Muhammed; Daula, A F M Shahid Ud; Singh, Randhir

doi:10.1016/j.prmcm.2023.100244

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…The rhizomes of Z. roseum are used by traditional healers in Bangladesh to cure rheumatic diseases, asthma, and wounds ( Al-Amin et al, 2019 ). The acute toxicity assessment of this plant’s rhizomes indicates that they are safe for human consumption ( Amanat et al, 2023 ). Despite the extensive historical usage of Z. roseum in traditional medicine, there remains a significant lack of understanding regarding the majority of its pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols and extracts from Zingiber roseum (Roxb.) Roscoe leaf mitigate pain, inflammation and pyrexia by inhibiting cyclooxygenase-2: an in vivo and in silico studies

Ahmed,

Rahman

et al. 2024

Front. Pharmacol.

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Zingiber roseum (Roxb.) Roscoe, a perennial herb from the Zingiberaceae family, has a long history of traditional use in the treatment of several ailments including pain, inflammation, fever, cough, arthritis, skin diseases, and liver infections. This study sought to confirm the efficacy of Zingiber roseum (Roxb.) Roscoe leaves methanol extract (ZrlME) as reported in traditional usage by evaluating its analgesic, anti-inflammatory, and antipyretic capabilities. In addition, in silico molecular docking of the metabolites identified in ZrlME was studied to verify the experimental outcomes. ZrlME demonstrated strong dose-dependent analgesic efficacy against all analgesic tests. ZrlME (400 mg/kg) showed higher anti-inflammatory activity than the standard in the carrageenan-induced paw edema test model. A significant reduction of rectal temperature (3.97°F↓) was also recorded at the same dose of ZrLME after 24 h of treatment. Seven polyphenolic metabolites were identified and quantified by HPLC-DAD analysis, including 3, 4- dihydroxy benzoic acid, (-) epicatechin, rutin hydrate, p-coumaric acid, trans-ferulic acid, rosmarinic acid, and myricetin. Strong binding affinities (ranges from −5.8 to −8.5 Kcal/mol) between the aforesaid polyphenols and cyclooxygenase-2 were discovered. Moreover, molecular dynamics simulations (MDS) demonstrated that these polyphenols exhibit significant COX-2 inhibitory activity due to their high stability in the COX-2 active site. In computational prediction, the polyphenols were also found to be nontoxic, and a variety of biological activities, such as antioxidant, analgesic, anti-inflammatory, antipyretic, and hepatoprotective, were observed. The results of this study revealed that ZrlME possesses notable analgesic, anti-inflammatory, and antipyretic properties.

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Section: Introductionmentioning

confidence: 99%

Polyphenols and extracts from Zingiber roseum (Roxb.) Roscoe leaf mitigate pain, inflammation and pyrexia by inhibiting cyclooxygenase-2: an in vivo and in silico studies

Ahmed,

Rahman

et al. 2024

Front. Pharmacol.

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“…According to conventional medicine, earthworm death rates show a similarity between Albendazole and a methanol extract. The worm experiences flaccid paralysis due to Albendazole, leading to peristalsis, ultimately evacuating the worm [37] . On P. posthuma worm, MVS anthelmintic activity has been determined.…”

Section: Resultsmentioning

confidence: 99%

“…The worm experiences flaccid paralysis due to Albendazole, leading to peristalsis, ultimately evacuating the worm. [37] On P. posthuma worm, MVS anthelmintic activity has been determined. The concentration of the extract, which ranged from 15 to 200 mg/ml, was shown to be directly proportional to the level of anthelmintic action.…”

Section: Anthelminthic Studymentioning

confidence: 99%

Unveiling the Anthelminthic Potential of Merremia vitifolia Stem through in Vitro and in Silico Approach

Islam,

Ahmed

et al. 2023

Chemistry & Biodiversity

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This study aimed to assess the anthelmintic activity of methanol extracts from Merremia vitifolia stems using a combination approach encompassing experimental, in vitro, and in silico evaluations. Despite the well‐recognized pharmacological properties of M. vitifolia, its potential as an anthelmintic agent remained unexplored. This plant’s anthelmintic potential was assessed on adult earthworms (Pheretima posthuma), revealing a dose‐dependent reduction in spontaneous motility leading to paralysis and eventual mortality. The most effective dose of M. vitifolia (200 mg/ml) for anthelmintic effects on Pheretima posthuma was identified. Complementary in silico investigations were also conducted, employing Autodock PyRx 0.8 for docking studies of reported M. vitifolia compounds. Notably, quercetin emerged as a promising candidate with superior binding energies against β‐tubulin (‐8.3 KCal/mol). Moreover, this comprehensive research underlines the anthelmintic potential of Merremia vitifolia stem extract and highlights quercetin as a noteworthy compound for further investigation in the quest for novel anthelmintic agents.

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GC‐MS Assisted Determination of 26 Compounds in Phlomis Stewartii Extract Exhibiting Antioxidant, Antifungal, and Antibacterial Properties

Farooq,

Ali,

Ullah

et al. 2024

Chemistry & Biodiversity

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Medicinal plants have long been studied for their therapeutic benifits. The present research aims to unveil complex phytochemical profile and therapeutic properties of ethyl acetate fraction of Phlomis stewartii, an important medicinal plant. In this context, the Gas Chromatography‐Mass Spectrometry (GC‐MS) analysis of the fraction identified 26 compounds. Additionally, the fraction exhibited concentration dependent antioxidant activity with an IC50 value lower than the standard antioxidant butylated hydroxytoluene. The antifungal activity of the fraction examined against F. oxysporum, A. alternate, and R. solani resulted in almost complete inhibition (>90%) of fungal growth. Furthermore, the fraction exhibited significant antibacterial potential against B. subtilus, S. aureus, E. coli, and S. dysenteriae, with inhibition zones of 18±0.22, 17±0.22, 12±0.11, and 10±0.12, respectively. Briefly, the plant extract was found to be highly potent, particularly in its antifungal action. Further studies, including natural products isolation coupled with bioassays, are recommended for promising drug candidates discovery.

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Acute toxicity assessment of methanolic extract of Zingiber roseum (Roscoe.) rhizome in swiss albino mice

Cited by 7 publications

References 45 publications

Polyphenols and extracts from Zingiber roseum (Roxb.) Roscoe leaf mitigate pain, inflammation and pyrexia by inhibiting cyclooxygenase-2: an in vivo and in silico studies

Polyphenols and extracts from Zingiber roseum (Roxb.) Roscoe leaf mitigate pain, inflammation and pyrexia by inhibiting cyclooxygenase-2: an in vivo and in silico studies

Unveiling the Anthelminthic Potential of Merremia vitifolia Stem through in Vitro and in Silico Approach

GC‐MS Assisted Determination of 26 Compounds in Phlomis Stewartii Extract Exhibiting Antioxidant, Antifungal, and Antibacterial Properties

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