Acute Toxicity (LD50) Studies Using Swiss Albino Mice and Brine Shrimp Lethality (LC50 and LC90) Determination of the Ethanol Extract of Stem Bark of Echinaceae angustifolia DC

Zakari, Abdu; Kubmarawa, D.

doi:10.4172/2329-6836.1000240

Cited by 9 publications

(9 citation statements)

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“…Toxicity of a chemical compound to be used as corrosion inhibitor can be assessed using its lethal and ethical concentrations designated as LC 50 and EC 50 , respectively [41,42]. LC 50 represents the concentration of substance that causes demise of 50% of living population and EC 50 denotes the chemical concentration that adversely affects the growth of the living population [43][44][45]`. Obviously, inferior LC 50 / EC 50 magnitude indicate superior sensitive toxicity and vice versa.…”

Section: Assessment Of Sustainable Corrosion Inhibitors: Ospar and Teach Commissionsmentioning

confidence: 99%

Recent developments in sustainable corrosion inhibitors: design, performance and industrial scale applications

et al. 2021

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Section: Assessment Of Sustainable Corrosion Inhibitors: Ospar and Teach Commissionsmentioning

confidence: 99%

Recent developments in sustainable corrosion inhibitors: design, performance and industrial scale applications

et al. 2021

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“…The experimental procedures relating to the animals were authorized by the Ethical committee of National Institute for Pharmaceutical Research and Development (NIPRD), Abuja-Nigeria before starting the study and were conducted under the internationally accepted principles for laboratory animal use and care (EEC Directive of 1986; 86/609/EEC) [7].…”

Section: Laboratory Animals Used In the Researchmentioning

confidence: 99%

“…The mice were infected intraperitoneally with standard inoculums of lx10 7 Plasmodium bergheiberghei NK 65 infected erythrocytes on the first day (day 0). Seventy-two hours (72h) later, the mice were divided into 5 groups of six mice each.…”

Section: G Evaluation Of Schizontocidal Activity Of the Plants Extramentioning

confidence: 99%

“…[3]. The in vivo acute toxicity and in vitro cytotoxicity of methanol extract of E. angustifolia DC was reported indicating its potentials use in pharmaceutical and toxicological studies [7]. Some clinical trials on the use of Echinacea preparations for the prevention and treatment of upper respiratory tract infections were reported to have high activity as compared to the control group [1].…”

Section: Introductionmentioning

confidence: 99%

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An in Vivo Studies on the Sensitivity Pattern of Plasmodium Bergei to Stem Bark Extract of Echinaceae Angustifolia DC (Compositae)

2017

International Journal of Medicinal Plants and Natural Products

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“…1 Human malaria is caused by single-celled parasites, belonging to the genus Plasmodium. 2 In its different specific and clinical guises, malaria is one of the strongest selective forces to have shaped our recent evolution. 3 There are renewed attempts to control and eventually eradicate what remains one of the world's biggest killer disease.…”

Section: Introductionmentioning

confidence: 99%

In vivo Evaluation of Antiplasmodial Properties of Myosotis scorpioides L. (Boraginaceae) Extract in Albino Mice Infected with Plasmodium berghei

Zakari¹,

Isyaka²,

Kendeson³

et al. 2018

TJNPR

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Myosotis scorpioides L commonly called water forget-me-not or true forget-me-not has been claimed by Traditional Medicine Practitioners (TMP) in Adamawa State to cure malaria. It is a herbaceous perennial flowering plant in the borage family (Boraginaceae). The present study was undertaken to scientifically verify the claimed ethnomedicinal use of the plant as antimalarial. The crude powdered sample (whole plant) of Myosotis scorpioides was extracted with methanol in a Soxhlet extractor. The concentrated extract was screened for the presence of secondary metabolites, tested for the median lethal dose (LD50) and antimalarial activity using Swiss albino mice. The result of the phytochemical screening indicated the presence of alkaloids, terpenes, tannins, flavonoids, saponins and anthraquinones. The result of the suppressive test (early malaria infection) showed a significant percentage suppression compared to the control with values of 49.91%, 56.72%, and 65.63% at the doses of 100 mg/kg, 150 mg/kg, and 250 mg/kg, respectively. The result of the prophylactic (residual malaria infection) tests showed a significant level of inhibition compared to the control (43.22%, 52.45%, and 85.70%) for the three doses. The curative (established malaria infection) tests also showed a significant level of parasite suppression compared to the control with percentage suppression of 66.73%, 70.20%, and 73.96% at 100, 150, and 250 mg/kg, respectively. The present study has validated the use of Myosotis scorpioides as remedy to malaria infection by the traditional medicine practitioners in Adamawa, State Nigeria.

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Acute Toxicity (LD50) Studies Using Swiss Albino Mice and Brine Shrimp Lethality (LC50 and LC90) Determination of the Ethanol Extract of Stem Bark of Echinaceae angustifolia DC

Cited by 9 publications

References 0 publications

Recent developments in sustainable corrosion inhibitors: design, performance and industrial scale applications

Recent developments in sustainable corrosion inhibitors: design, performance and industrial scale applications

An in Vivo Studies on the Sensitivity Pattern of Plasmodium Bergei to Stem Bark Extract of Echinaceae Angustifolia DC (Compositae)

In vivo Evaluation of Antiplasmodial Properties of Myosotis scorpioides L. (Boraginaceae) Extract in Albino Mice Infected with Plasmodium berghei

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