Acute transverse myelitis

Cree, Bruce A.C.; Wingerchuk, Dean M.

doi:10.1212/01.wnl.0000194615.51750.f8

Cited by 22 publications

(24 citation statements)

References 12 publications

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“…However, heterogeneity of patient demographics, treatment response, and outcome suggests that this diagnosis incorporates several underlying entities. As pointed out in a 2006 editorial in Neurology entitled “Is the idiopathic form vanishing?” due to advancements in our understanding of the pathogenesis of disease associated transverse myelitis, and as increasingly sensitive and specific microbial assays and autoimmune markers are developed, idiopathic transverse myelitis may in future represent a lesser proportion of myelopathy presentations .…”

Section: Clinical and Imaging Features Of Idiopathic And Disease Assomentioning

confidence: 99%

MRI in transverse myelitis

Goh

Desmond

Phal

2014

Magnetic Resonance Imaging

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Transverse myelitis is an acute inflammatory disease of the spinal cord, characterized by rapid onset of bilateral neurological symptoms. Weakness, sensory disturbance, and autonomic dysfunction evolve over hours or days, most progressing to maximal clinical severity within 10 days of onset. At maximal clinical severity, half will have a paraparesis, and almost all patients have sensory disturbance and bladder dysfunction. Residual disability is divided equally between severe, moderate and minimal or none. The causes of transverse myelitis are diverse; etiologies implicated include demyelinating conditions, collagen vascular disease, and parainfectious causes, however, despite extensive diagnostic work-up many cases are considered idiopathic. Due to heterogeneity in pathogenesis, and the similarity of its clinical presentation with those of various noninflammatory myelopathies, transverse myelitis has frequently been viewed as a diagnostic dilemma. However, as targeted therapies to optimize patient outcome develop, timely identification of the underlying etiology is becoming increasingly important. In this review, we describe the imaging and clinical features of idiopathic and disease-associated transverse myelitis and its major differentials, with discussion of how MR imaging features assist in the identification of various sub-types of transverse myelitis. We will also discuss the potential for advanced MR techniques to contribute to diagnosis and prognostication.

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Section: Clinical and Imaging Features Of Idiopathic And Disease Assomentioning

confidence: 99%

MRI in transverse myelitis

Goh

Desmond

Phal

2014

Magnetic Resonance Imaging

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“…This study is limited by a small sample size and confounded by imbalance between the methylprednisolone-treated and untreated groups with respect to severity of myelitis and age at presentation. (Cree and Wingerchuk, 2005). When the TMCWG-proposed diagnostic criteria are applied to a cohort of patient with ATM, a relatively small proportion of patients meet criteria for idiopathic transverse myelitis.…”

Section: Estimates Of Prevalencementioning

confidence: 99%

Acute inflammatory myelopathies

Cree

2014

Handbook of Clinical Neurology

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“…In 1948, a neurologist at St. Charles Hospital in London, Dr. Succett-Kaye, first used the term "acute transverse myelitis"because of a "bandlike horizontal area of altered sensation" (Kerr, 2006). Currently, 1,400 new cases of TM are diagnosed in the United States each year (Cree & Wingerchuck, 2005). The disease peaks between ages 10-19 years and 30-39 years.…”

Section: History and Epidemiologymentioning

confidence: 99%

“…Although considerable progress has been made regarding the discovery of the immune-mediated response, the exact cause of the inflammatory reaction in the spinal cord remains a mystery. Several studies suggest that there are a number of infections that elicit the immunopathogenesis that occurs with TM (Cree & Wingerchuck, 2005;Hammerstedt, Edlow, & Cusick, 2005;Krishnan et al, 2004).…”

Section: Pathophysiologymentioning

confidence: 99%

“…Because the inflammation occurs in a focal area of the spinal cord, there will be a clearly defined sensory level of the symptoms. Also, the patient may exhibit paresthesias such as burning and sensations of tingling (Cree & Wingerchuck, 2005). Early symptoms of TM are urinary frequency or incontinence and bilateral lower-extremity weakness.…”

Section: Clinical Presentation Of Transverse Myelitismentioning

confidence: 99%

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Identifying Transverse Myelitis in the Emergency Care Arena

Waldrup¹

2009

Advanced Emergency Nursing Journal

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Transverse myelitis (TM) is a neurological syndrome involving destruction of the anterior and posterior (transverse) segments of the spinal cord. The objective of this article is to educate emergency nurses and nurse practitioners about how to recognize, diagnose, and treat TM. A comparison of the neurological findings of TM and Guillain-Barré syndrome is presented. In addition, this article will include an algorithm and specific diagnostic criteria to assist in the diagnosis of acute idiopathic TM.

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Acute transverse myelitis

Cited by 22 publications

References 12 publications

MRI in transverse myelitis

MRI in transverse myelitis

Acute inflammatory myelopathies

Identifying Transverse Myelitis in the Emergency Care Arena

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