Acute treatment with alcohol affects calcium signaling and contraction associated with apoptosis in vas deferens of periadolescent rats

Verde, Luciana Ferreira; Lopes, Guiomar Silva; Ihara, Sílvia Saiuli Miki; Jurkiewicz, Neide Hyppolito; Jurkiewicz, Aron

doi:10.1016/j.ejphar.2014.04.009

Cited by 4 publications

(2 citation statements)

References 33 publications

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Section: Muscle Types and Their Mechanisms For Contractionmentioning

confidence: 99%

“…With respect to ethanol-induced modulation of E-C coupling, it was shown that acute and heavy alcohol consumption in peri-adolescent male Wistar rats caused decreased Ca 2+ signaling in the vas deferens ( 172 ). A similar ethanol-induced impairment of E-C coupling was reported for the prostate and epididymis ( 167 , 172 ). This impaired ethanol-induced Ca 2+ influx was found to be mediated primarily by DHPR with little involvement of IP 3 R- and RyR-controlled SR Ca 2+ stores ( 167 ).…”

Section: Muscle Types and Their Mechanisms For Contractionmentioning

confidence: 99%

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Alcohol Use Disorders and Their Harmful Effects on the Contractility of Skeletal, Cardiac and Smooth Muscles

Alleyne¹,

Dopico²

2021

Adv. Drug Alcohol Res.

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Alcohol misuse has deleterious effects on personal health, family, societal units, and global economies. Moreover, alcohol misuse usually leads to several diseases and conditions, including alcoholism, which is a chronic condition and a form of addiction. Alcohol misuse, whether as acute intoxication or alcoholism, adversely affects skeletal, cardiac and/or smooth muscle contraction. Ethanol (ethyl alcohol) is the main effector of alcohol-induced dysregulation of muscle contractility, regardless of alcoholic beverage type or the ethanol metabolite (with acetaldehyde being a notable exception). Ethanol, however, is a simple and “promiscuous” ligand that affects many targets to mediate a single biological effect. In this review, we firstly summarize the processes of excitation-contraction coupling and calcium homeostasis which are critical for the regulation of contractility in all muscle types. Secondly, we present the effects of acute and chronic alcohol exposure on the contractility of skeletal, cardiac, and vascular/ nonvascular smooth muscles. Distinctions are made between in vivo and in vitro experiments, intoxicating vs. sub-intoxicating ethanol levels, and human subjects vs. animal models. The differential effects of alcohol on biological sexes are also examined. Lastly, we show that alcohol-mediated disruption of muscle contractility, involves a wide variety of molecular players, including contractile proteins, their regulatory factors, membrane ion channels and pumps, and several signaling molecules. Clear identification of these molecular players constitutes a first step for a rationale design of pharmacotherapeutics to prevent, ameliorate and/or reverse the negative effects of alcohol on muscle contractility.

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Section: Muscle Types and Their Mechanisms For Contractionmentioning

confidence: 99%

Section: Muscle Types and Their Mechanisms For Contractionmentioning

confidence: 99%

Alcohol Use Disorders and Their Harmful Effects on the Contractility of Skeletal, Cardiac and Smooth Muscles

Alleyne¹,

Dopico²

2021

Adv. Drug Alcohol Res.

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Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

Huang

Ding

et al. 2019

Part & Part Syst Charact

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When nanomaterials are exposed to complex systems, such as food, they may cause significant changes in physical and chemical properties and even toxicity. The toxicity evaluation of complex systems is urgent. Unfortunately, so far, there is no database established about the toxicity changes of nanoparticles in composite systems. In this paper, the changes and toxicity mechanism of zinc oxide nanoparticles (ZnO NPs) in a composite system are studied. The results show that the dissolution of zinc ions (Zn2+) in acidic systems (vitamin C, tartaric acid, or citric acid) increases the toxicity of ZnO NPs. However, the toxicity of ZnO NPs is reduced by the complexation effect with Zn2+ in phosphoric acid, phosphate, and glutathione systems. The influence of titanium dioxide nanoparticles (TiO2 NPs) on the toxicity of ZnO NPs depends on size and surface properties. In brief, the intracellular Zn2+ homeostasis level is the decisive factor in determining the toxicity change in complex systems. The results indicate that the toxicity changes are very different in combined systems, which may have potential food safety issues, especially for unstable nanoparticles.

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Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue

Aydinoglu

Kıroğlu

Astarcı

et al. 2015

European Journal of Pharmacology

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Acute treatment with alcohol affects calcium signaling and contraction associated with apoptosis in vas deferens of periadolescent rats

Cited by 4 publications

References 33 publications

Alcohol Use Disorders and Their Harmful Effects on the Contractility of Skeletal, Cardiac and Smooth Muscles

Alcohol Use Disorders and Their Harmful Effects on the Contractility of Skeletal, Cardiac and Smooth Muscles

Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

Effects of ethanol on RhoA/Rho-kinase-mediated calcium sensitization in mouse lung parenchymal tissue

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