Acute tryptophan depletion does not alter central or plasma brain-derived neurotrophic factor in the rat

Cahir, Marie; Ardis, T.C.; Elliott, J.; Kelly, Carmel; Reynolds, Gavin P.; Cooper, Stephen

doi:10.1016/j.euroneuro.2007.07.006

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…Two studies [111,114] showed that brain-derived neurotrophic factor (BDNF) might play a role in the effects of ATD. In contrast, the study of Chair et al [115] showed that plasma or central BDNF protein levels in the hippocampus and midbrain were not altered by ATD. Furthermore, based on a study of D'Souza et al [116], Chair et al [115] speculated that the effects of ATD on the 5-HT2A receptor might be mediated by corticosterone.…”

Section: -Ht Mediated Instead Of 5-ht Inducedmentioning

confidence: 88%

“…In contrast, the study of Chair et al [115] showed that plasma or central BDNF protein levels in the hippocampus and midbrain were not altered by ATD. Furthermore, based on a study of D'Souza et al [116], Chair et al [115] speculated that the effects of ATD on the 5-HT2A receptor might be mediated by corticosterone. In addition, Riedel et al [117] showed that ATD blocked the stress-induced cortisol response which is indeed partly 5-HT2A mediated.…”

Section: -Ht Mediated Instead Of 5-ht Inducedmentioning

confidence: 88%

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The Effects of Acute Tryptophan Depletion on Brain Activation During Cognition and Emotional Processing in Healthy Volunteers

Evers¹,

Sambeth²,

Ramaekers³

et al. 2010

CPD

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Acute tryptophan depletion (ATD), a method to temporarily lower central serotonin levels, has been used to study the functioning of the serotonergic system. Relatively recent studies that examined the effects of ATD on brain activation associated with cognitive and emotional processing in healthy volunteers are reviewed. An overview of the findings in healthy volunteers is important for the interpretation of the effect of ATD on brain activation in patients with an affective disorder, such as major depression. These studies show that during response control and negative feedback processing ATD modulates the BOLD response in the inferior/orbitofrontal cortex, the anterior cingulate cortex and the dorsomedial prefrontal cortex. During emotional processing, it is consistently found that ATD modulates the BOLD response in the amygdala. These brain regions also show abnormal activation in depressed patients. However, at the moment it remains unclear if the changes induced by ATD are related to decreased basal serotonin (5-HT) release or the result of other biochemical changes that are mediated by ATD. Future studies should implement methodological improvements, explore the possibilities of new promising imaging techniques and expand investigations into the effects of ATD on basal 5-HT release and other biochemical mechanisms that might be modulated by ATD.

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Section: -Ht Mediated Instead Of 5-ht Inducedmentioning

confidence: 88%

Section: -Ht Mediated Instead Of 5-ht Inducedmentioning

confidence: 88%

The Effects of Acute Tryptophan Depletion on Brain Activation During Cognition and Emotional Processing in Healthy Volunteers

Evers¹,

Sambeth²,

Ramaekers³

et al. 2010

CPD

View full text Add to dashboard Cite

show abstract

“…Animal data suggest that ATD's effects are not mediated by altering noradrenaline, dopamine or brain-derived neurotrophic factor levels (Ardis et al 2009;Cahir et al 2008). Continuous cerebrospinal fluid sampling of normal volunteers undergoing TD showed that both central TRP and the principal 5-HT metabolite 5-hydroxy indoleacetic acid were substantially reduced (Carpenter et al 1998;Williams et al 1999).…”

Section: Introductionmentioning

confidence: 96%

Effects of acute tryptophan depletion in serotonin reuptake inhibitor-remitted patients with generalized anxiety disorder

et al. 2009

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Acute Tryptophan Depletion Reduces Nitric Oxide Synthase in the Rat Hippocampus

et al. 2013

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Acute tryptophan depletion (ATD) is extensively used to investigate the role of central serotonin (5-HT). However, several studies reported that ATD had no significant effect on central 5-HT concentration and some ATD-induced changes was independent of 5-HT in the rodent brain. Therefore, the potential mechanism of ATD might not be ascribed solely to changes in the central 5-HT system. In recent studies, evidence suggests that nitric oxide synthase (NOS) is closely associated with ATD-induced changes in modulation of cerebral blood flow and metabolism, cognitive, and locomotor activity. Thus, NOS is implicated to be an underlying factor contributing to ATD-induced changes. In the present study, the effect of ATD upon central NOS levels in the rat was evaluated. Male Sprague-Dawley (SD) rats were orally administered a tryptophan-free protein-carbohydrate mixture. Then, ATD effects upon affective behavior and spatial memory were assessed by the forced swimming test (FST) and Morris water maze test, respectively. Further, NOS activity and neuronal NOS (nNOS) protein levels in the hippocampus were measured after ATD. Our experimental results showed that ATD had no influence on affective behavior in the FST or spatial memory in SD rats. Interestingly, a significant reduction of both constitutive NOS activity and nNOS protein levels after ATD was found in the hippocampus. These findings demonstrate ATD does not influence affective behavior and spatial memory despite a direct effect on hippocampal NOS. Our study might provide a valuable clue for exploring earlier reported ATD-induced behavioral and neurochemical changes in rodents.

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Acute tryptophan depletion does not alter central or plasma brain-derived neurotrophic factor in the rat

Cited by 12 publications

References 32 publications

The Effects of Acute Tryptophan Depletion on Brain Activation During Cognition and Emotional Processing in Healthy Volunteers

The Effects of Acute Tryptophan Depletion on Brain Activation During Cognition and Emotional Processing in Healthy Volunteers

Effects of acute tryptophan depletion in serotonin reuptake inhibitor-remitted patients with generalized anxiety disorder

Acute Tryptophan Depletion Reduces Nitric Oxide Synthase in the Rat Hippocampus

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