Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease

Kashyap, Isha; Deb, Rachayeeta; Battineni, Abhigna; Nagotu, Shirisha

doi:10.1007/s00438-023-02059-5

Mol Genet Genomics

2023

DOI: 10.1007/s00438-023-02059-5

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Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease

Isha Kashyap,

Rachayeeta Deb,

Abhigna Battineni

et al.

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2024

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Cited by 3 publications

References 92 publications

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The mechanism of low temperature enhances dough aromas during fermentation by Pichia kudriavzevii: Sugar and amino acid metabolism, acid utilization and alcohol production

Xu,

Zhao,

et al. 2024

Food Bioscience

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The mechanism of low temperature enhances dough aromas during fermentation by Pichia kudriavzevii: Sugar and amino acid metabolism, acid utilization and alcohol production

Xu,

Zhao,

et al. 2024

Food Bioscience

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Anti-obesity effect of Lactobacillus fermented Paeonia japonica, Cnidium officinale, and Angelica gigas nakai

Choi,

Kim,

Shin

et al. 2024

J. People Plants Environ

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Background and objective: This study evaluated the effects of Paeonia japonica, Cnidium officinale, and Angelica gigas nakai extracts fermented with Lactobacillus in obese mice induced by high-fat diets. Among the fermented liquids, Lactobacillus Paeonia japonica (LBPJ) exhibited high antioxidant activity and a significant total polyphenol content.Methods: Mice were divided into five groups: normal (NOR), high-fat diet (HFD), high-fat Lactobacillus Paeonia japonica (HLBPJ), high-fat Lactobacillus Cnidium officinale (HLBCO), and high-fat Lactobacillus Angelica gigas nakai (HLBAG). Obesity was induced with a high-fat diet for 8-weeks, and the fermented liquid was administered orally at a dose of 100 mg/kg per day.Results: The high-fat diet group showed significant weight gain and the group receiving the fermented liquid did not show weight loss. Blood tests showed increased levels of total cholesterol, triglyceride, and high-density lipoprotein (HDL) and decreased levels of low-density lipoprotein (LDL) in the HLBCO group. Creatinine levels remained unchanged, blood urea nitrogen (BUN) levels decreased, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels increased. As a result of PCR analysis of liver tissue, LBPJ fermented liquid effectively reduced fat accumulation in the liver and inhibited the expression of fat-related genes such as PPARα, PPARγ, CPT-2, and HSL.Conclusion: These findings suggest that fermented liquids containing Angelica gigas nakai extracts prevent obesity by reducing body fat and blood sugar levels.

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High Levels of Erucic Acid Cause Lipid Deposition, Decreased Antioxidant and Immune Abilities via Inhibiting Lipid Catabolism and Increasing Lipogenesis in Black Carp (Mylopharyngodon piceus)

Liu,

Ma,

et al. 2024

Animals

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This study investigated the effects of dietary erucic acid (EA) on growth, lipid accumulation, antioxidant and immune abilities, and lipid metabolism in black carp fed six diets containing varying levels of EA (0.00%, 0.44%, 0.81%, 1.83%, 2.74%, and 3.49%), for 8 weeks. Results showed that fish fed the 3.49% EA diet exhibited lower weight gain, compared to those fed the 0.81% EA diet. In a dose-dependent manner, the serum triglycerides and total cholesterol were significantly elevated in the EA groups. The 1.83%, 2.74%, and 3.49% levels of EA increased alanine aminotransferase and aspartate aminotransferase activities, as well as decreased acid phosphatase and alkaline phosphatase values compared to the EA-deficient group. The hepatic catalase activity and transcriptional level were notably reduced, accompanied by increased hydrogen peroxide contents in the EA groups. Furthermore, dietary EA primarily increased the C22:1n-9 and C20:1n-9 levels, while decreasing the C18:0 and C18:1n-9 contents. In the EA groups, expressions of genes, including hsl, cpt1a, cpt1b, and ppara were downregulated, whereas the fas and gpat expressions were enhanced. Additionally, dietary EA elevated the mRNA level of il-1β and reduced the expression of il-10. Collectively, high levels of EA (2.74% and 3.49%) induced lipid accumulation, reduced antioxidative and immune abilities in black carp by inhibiting lipid catabolism and increasing lipogenesis. These findings provide valuable insights for optimizing the use of rapeseed oil rich in EA for black carp and other carnivorous fish species.

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Acyl CoA oxidase: from its expression, structure, folding, and import to its role in human health and disease

Cited by 3 publications

References 92 publications

The mechanism of low temperature enhances dough aromas during fermentation by Pichia kudriavzevii: Sugar and amino acid metabolism, acid utilization and alcohol production

The mechanism of low temperature enhances dough aromas during fermentation by Pichia kudriavzevii: Sugar and amino acid metabolism, acid utilization and alcohol production

Anti-obesity effect of Lactobacillus fermented Paeonia japonica, Cnidium officinale, and Angelica gigas nakai

High Levels of Erucic Acid Cause Lipid Deposition, Decreased Antioxidant and Immune Abilities via Inhibiting Lipid Catabolism and Increasing Lipogenesis in Black Carp (Mylopharyngodon piceus)

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