ADAMTS proteases: key roles in atherosclerosis?

Abstract

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases are secreted enzymes that regulate extracellular matrix turnover by degrading specific matrix components. Roles for the proteases in inflammation and atherosclerosis have been suggested by a number of recent studies, and the role of ADAMTS-4 and -5 in the breakdown of aggrecan and subsequent degradation of cartilage during osteoarthritis has also been established. The ability of the ADAMTS proteases to degrade versican, the primary proteoglycan in the vasculature, is thought to be central to any hypothesized role for the proteases in atherosclerosis. In this review, we introduce the structure and function of the ADAMTS family of proteases and review the literature that links them with inflammation and atherosclerosis.

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

“…ADAMTS (a disintegrin and metalloprotease with thrombospondin motif) are a group of proteins closely related to ADAMs (see for a review Apte et al, 2009;Jones and Riley, 2005;Porter et al, 2005;Salter et al, 2010;Shiomi et al, 2010;Tortorella et al, 2009;Wagstaff et al, 2011).…”

Genome-Wide Association Scan for Survival on Dialysis in African-Americans with Type 2 Diabetes

“…Proteases from the ADAMTS family regulate ECM turnover in atherosclerotic plaque [15], and hyaluronic acid (encoded by HAS2 gene) is a prominent constituent of the ECM in atherosclerotic vascular lesions [16]. Our analysis found several SNPs clustered near the ADAMTS5 gene (rs6816344, rs1452093, rs9977499, rs1817114, rs2830881) and a single SNP located near the HAS2 gene (rs17232789) to have significant correlations with survival.…”

Plasmatic MicroRNA Signatures in Elderly People with Stable and Unstable Angina

“…ADAMTS family are circulating plasma enzymes responsible for processing procollagens and von Willebrand factor, and involved in cleavage of proteoglycans. 17,18) Numerous studies have shown that ADAMTS were key participants in the pathogenesis of vascular diseases, including atherosclerosis, aneurismal change, and restenosis. [19][20][21] ADAMTS proteases contributed to the plaque destabilization by weakening the fibrous cap, and expressed higher in coronary atherosclerotic plaques of ACS patients than SA patients.…”