Adaptation of visual cortex to damage of visual pathways in suprasellar tumors before and after gamma knife radiosurgery

Speckter, Herwin; Bido, Jose; Hernandez, Giancarlo; Rivera, Diones; Suazo, Luis; Valenzuela, Santiago; Escoto, Remberto; Oviedo, Jairo; Gonzalez, Cesar; Foerster, Bernd; Stoeter, P.

doi:10.1007/s11060-019-03092-4

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…TI controls the MR signal output of different tissues and by changing this parameter, the suppression of water, fat, and other tissues is attainable. [ 31 ] We noted that OATPs generate T1‐weighted signals over a range of TI; therefore, OATP1B1 and OATP1B3‐transplanted cells surrounding tissue signals can be suppressed by changing the TI values of T1‐weighted images. Another future aspect that needs to be considered is the initial bolus doses of Gd‐EOB‐DTPA and its pharmacokinetics for quantitative data acquisition.…”

Section: Discussionmentioning

confidence: 99%

Utility of Hepatic Transporters as Multimodal Gene Reporters for Cell‐Based Medicine

et al. 2020

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Hepatic transporters facilitate the uptake of xenobiotic compounds and confer immense potential as multimodality reporters, as they can uptake multitude of bioluminescent, fluorescence, near Infra-red (NIR), and magnetic resonance imaging (MRI) compounds. Here, it is aimed to identify the prospects of three human hepatocyte membrane proteins, organic anion transporters (OATP) 1B1, OATP1B3, and sodium-taurocholate cotransporting polypeptide in tracing the transplanted cells dynamics, by the uptake of clinically approved MRI compound, gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (GD-EOB DTPA) or NIR fluorescent dye, Indocyanine Green (ICG). First, OATP1B1 is introduced as new MRI reporter which is the human orthologue of previously established rodent (Oatp1a1) reporter. Comparative sequential assays by assimilating MR image parameters reveal OATP1B3 as superior reporter on T1-weighted images and display highest contrast enhancement reported to-date when using a clinical 3T MR scanner (≈21-fold in vitro; ≈8-fold in vivo). Stably expressing these hepatic transporters have no effect on human adipose derived mesenchymal stem cells (hADSCs) characteristics. However, only OATP1B3 able to trace as few as 2 × 10 5 hADSCs intramuscular xenograft survival time on NIR and 3T MRI. These data suggest that OATP1B3 is relatively a robust Gd-EOB-DTPA/ICG-dependent multimodality reporter in visualizing dynamic processes for cell-based therapies.

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Section: Discussionmentioning

confidence: 99%

Utility of Hepatic Transporters as Multimodal Gene Reporters for Cell‐Based Medicine

et al. 2020

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“…We also analyzed the percent signal change within the brain areas involved in higher visual perception and processing, the cluster sizes of activated voxels in the calcarine fissure and lateralization indices in the occipital lobe. Based on the previous results [ 43 , 44 , 45 ], where effects of the suprasellar tumors also in the nonaffected occipital lobe where found, the higher brain areas not directly invaded by the tumor should also show significant effects. Although eccentricity mapping is not originally intended to activate higher visual areas, we assume that these areas should show lower activity due to reduced inputs from tumor-affected areas in the affected hemisphere.…”

Section: Introductionmentioning

confidence: 91%

“…Furthermore, in patients with a suprasellar tumor involving compression of the optic chiasm (meningioma and pituitary adenoma), functional connectivity within visual areas during rest significantly improved as a result of surgical treatment of the patients, which was consistent with an additional improvement of the visual abilities postoperatively [ 43 ]. Additionally, such patients showed reduced cortical thickness in some areas of the occipital lobe compared to healthy control subjects [ 44 ]. The volume of the grey matter can increase in consequence of decompression surgery, which also correlates with an improvement in visual abilities [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

fMRI Retinotopic Mapping in Patients with Brain Tumors and Space-Occupying Brain Lesions in the Area of the Occipital Lobe

Hense

Plank

Wendl

et al. 2021

Cancers

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Functional magnetic resonance imaging (fMRI) is a valuable tool in the clinical routine of neurosurgery when planning surgical interventions and assessing the risk of postoperative functional deficits. Here, we examined how the presence of a brain tumor or lesion in the area of the occipital lobe affects the results of fMRI retinotopic mapping. fMRI data were evaluated on a retrospectively selected sample of 12 patients with occipital brain tumors, 7 patients with brain lesions and 19 control subjects. Analyses of the cortical activation, percent signal change, cluster size of the activated voxels and functional connectivity were carried out using Statistical Parametric Mapping (SPM12) and the CONN and Marsbar toolboxes. We found similar but reduced patterns of cortical activation and functional connectivity between the two patient groups compared to a healthy control group. Here, we found that retinotopic organization was well-preserved in the patients and was comparable to that of the age-matched controls. The results also showed that, compared to the tumor patients, the lesion patients showed higher percent signal changes but lower values in the cluster sizes of the activated voxels in the calcarine fissure region. Our results suggest that the lesion patients exhibited results that were more similar to those of the control subjects in terms of the BOLD signal, whereas the extent of the activation was comparable to that of the tumor patients.

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“…The SIR sequence with subtraction of images with different TIs was described in 2017 (40) and used to study suprasellar tumors in 2018 (41).…”

Section: A B a Bmentioning

confidence: 99%

New options for increasing the sensitivity, specificity and scope of synergistic contrast magnetic resonance imaging (scMRI) using Multiplied, Added, Subtracted and/or FiTted (MASTIR) pulse sequences

Ma¹,

Shao²,

Fan³

et al. 2020

Quant Imaging Med Surg

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This paper reviews magnetic resonance (MR) pulse sequences in which the same or different tissue properties (TPs) such as T 1 and T 2 are used to contribute synergistically to lesion contrast. It also shows how synergistic contrast can be created with Multiplied, Added, Subtracted and/or fiTted Inversion Recovery (MASTIR) sequences, and be used to improve the sensitivity, specificity and scope of clinical magnetic resonance imaging (MRI) protocols. Synergistic contrast can be created from: (i) the same TP,

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Adaptation of visual cortex to damage of visual pathways in suprasellar tumors before and after gamma knife radiosurgery

Cited by 4 publications

References 27 publications

Utility of Hepatic Transporters as Multimodal Gene Reporters for Cell‐Based Medicine

Utility of Hepatic Transporters as Multimodal Gene Reporters for Cell‐Based Medicine

fMRI Retinotopic Mapping in Patients with Brain Tumors and Space-Occupying Brain Lesions in the Area of the Occipital Lobe

New options for increasing the sensitivity, specificity and scope of synergistic contrast magnetic resonance imaging (scMRI) using Multiplied, Added, Subtracted and/or FiTted (MASTIR) pulse sequences

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