2024
DOI: 10.26434/chemrxiv-2024-xmjml
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Adapting a trapped ion mobility spectrometry-Q-TOF for native mass spectrometry

Yu-Fu Lin,
Benjamin Jones,
Mark Ridgeway
et al.

Abstract: Native mass spectrometry (nMS) is increasingly popular for studying intact protein quaternary structure. When coupled with ion mobility, which separates ions based on their size, charge, and shape, it provides additional structural information on the protein complex of interest. In this study, we present a novel prototype TIMS (trapped ion mobility)-Quadrupole-SID (surface-induced dissociation)-Time of Flight (TIMS-Q-SID-TOF) instrument for nMS. The modifications include changing the TIMS cartridge from concav… Show more

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