The present study investigates the sustainable influence of human resources (HR) support on job satisfaction and work–life balance among female employees in Saudi Arabia, underlining its significance in advancing social sustainability within the workforce. It seeks to analyze the role of job satisfaction as a mediator and organizational policies as moderators in these relationships. This study analyzed data from a simple random sample of 145 employed women in different sectors in Saudi Arabia, utilizing exploratory and confirmatory factor analyses, as well as inferential statistical methods for hypotheses testing. We conducted an evaluation of mediating and moderating effects in the investigated relationships using the PROCESS macro for SPSS. The findings show a strong positive relationship between HR support, work–life balance, and job satisfaction in Saudi Arabia’s female workforce. The mediation function of job satisfaction in the relationship between HR support and work–life balance emphasizes the critical role of positive working experiences in achieving work–life balance. Furthermore, this research highlights organizational policies as a crucial mediator, indicating that implementing supportive and progressive policies might amplify the beneficial impacts of HR practices on work–life balance and job satisfaction. The present study enhances the existing body of knowledge by offering empirical findings on the importance of culturally customized sustainable HR practices and the crucial function of organizational policies in advancing gender equality and achieving a healthy work–life balance.