Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis
Elina Misicka,
Yunfeng Huang,
Stephanie Loomis
et al.
Abstract:Background and Objectives
Multiple sclerosis (MS) age at onset (AAO) is a clinical predictor of long-term disease outcomes, independent of disease duration. Little is known about the genetic and biological mechanisms underlying age of first symptoms. We conducted a genome-wide association study (GWAS) to investigate associations between individual genetic variation and the MS AAO phenotype.
Methods
The study population was comprised participants with MS in 6 clinical tr… Show more
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