Adaptive behavior impaired in children with low‐grade glioma

Lande, Roberto; Maurice‐Stam, Heleen; Marchal, Jan Pieter; Vuurden, D.G. van; Vandertop, W. Peter; Grootenhuis, Martha A.; Meeteren, Antoinette Y. N. Schouten–van

doi:10.1002/pbc.27419

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…Previous studies among PBTS with a comparable follow-up time (1–15 years) did report that recurrent neurosurgery, shunt revisions, and chemotherapy were associated with major disabilities and poorer motor skills. 3 , 15 , 28 We found these factors to be associated with fatigue in our cohort but not with participation or impairments in functioning. A potential explanation is the heterogeneity of our cohort with various types of brain tumors and/or overlap between treatment modalities, which challenges detecting relationships.…”

Section: Discussionmentioning

confidence: 46%

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Determinants of impairments in functioning, fatigue, and participation ability in pediatric brain tumor survivors

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Catsman‐Berrevoets

Maurice‐Stam

et al. 2021

Neuro-Oncology Advances

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Introduction Pediatric brain tumor survivors (PBTS) experience disease- and treatment-related sequelae. We aimed to investigate the occurrence of participation limitations, impairments in functioning, fatigue, and the association between patient, tumor- and treatment-related factors and these outcomes. Methods Children (4-18 years) after treatment for a brain tumor between 2005-2014 at the Erasmus Medical Center, Rotterdam, the Netherlands, were eligible. The parent-reported Child and Family Follow-up Survey developed to measure participation and impairments in functioning in youth with acquired brain injury, was used. Fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale. Associations with patient, tumor- and treatment-related factors were explored using univariable analyses. Results Ninety-one PBTS (median age: 11.3 years [range: 9.5-14.1], time since treatment: 3.9 years [range: 4-6.2]) were included (response rate: 55%). Participation limitations were reported in 53% and were associated with impairments in functioning (15-67%) (p≤0.01) and fatigue (p≤0.03). Parent- and child-reported fatigue was increased compared to normative values (p=≤0.02). History of hydrocephalus was associated with increased fatigue (p≤0.04). Younger age at diagnosis and longer time since diagnosis were associated with impairments in functioning and cognitive fatigue (p=<0.05). Participation limitations, impairments in functioning and fatigue were similar in PBTS who were <3 or ≥3 years since completion of treatment. Conclusion More than half of PBTS reported limited participation ability, which is associated with impairments in functioning and fatigue. The complication hydrocephalus seems to lead to more fatigue. Participation limitations, impairments in functioning and fatigue appear not to diminish in the longer term.

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Section: Discussionmentioning

confidence: 46%

“…We found that younger age at diagnosis (<6 years) was associated with more impairments in functioning, which is in accordance with previous studies in PBTS where younger age at treatment has been related to more disability. 3 , 28 …”

Section: Discussionmentioning

confidence: 99%

Determinants of impairments in functioning, fatigue, and participation ability in pediatric brain tumor survivors

Verwaaijen

Catsman‐Berrevoets

Maurice‐Stam

et al. 2021

Neuro-Oncology Advances

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“…There was a significant level of heterogen ity across the different studies (I 2 = 54%, p < 0.01) and no significant publication bias w identified t (15) = 0.36, p = 0.72, Figure S5a. 2021) [83] reported more than o independent cohort in their study [24,30,36,37,39,40,42,43,[45][46][47]49,[55][56][57][58]60,61,[63][64][65][66][70][71][72][73][74][75]77,83]. (a) Abso-lute risk-attention problems; (b) Absolute risk-emotional; (c) Absolute risk psychosocial problems…”

Section: Absolute Risk-attention Problemsmentioning

confidence: 98%

“…The publication bias was n significant, as revealed by Egger's test t (18) = 0.92, p = 0.369 (Figure S6a). 2021) [83] reported more than one independent cohort in their study [24,30,36,37,39,40,42,43,[45][46][47]49…”

Section: Standard Mean Difference-attention Problemsmentioning

confidence: 99%

“…(a-c) Absolute risk of pediatric brain tumor survivors having neurobehavioral impairment. Dessens et al (2016) [49] and Youn et al (2021)[83] reported more than one independent cohort in their study[24,30,36,37,39,40,42,43,[45][46][47]49,55-58,60,61,63-66,70-75,77,81-83]. (a) Abso-lute risk -attention problems; (b) Absolute risk-emotional; (c) Absolute risk-psychosocial problems.…”

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confidence: 99%

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Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis

Wang

Liu

Lee

et al. 2022

Cancers

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Purpose: The neurocognitive outcomes of pediatric brain tumor survivors have been extensively studied but the risk and predictors for neurobehavioral impairment are less clearly defined. We systematically analyzed the rates of emotional, psychosocial, and attention problems in pediatric brain tumor survivors. Methods: PubMed, Web of Science, Embase, Scopus, and Cochrane were searched for articles published between January 2012 to April 2022. Eligible studies reported neurobehavioral outcomes for PBTS aged 2 to <23 years with a brain tumor diagnosis before 18 years of age. A random-effect meta-analysis was performed in R. Results: The search yielded 1187 unique publications, of which 50 were included in the quantitative analysis. The estimated risk of having emotional, psychosocial, and attention problems were 15% (95%CI 10–20%), 12% (95%CI 9–16%), and 12% (95%CI 9–16%), respectively. PBTS were more likely to have emotional difficulties (Hedge’s g = 0.43 [95%CI 0.34–0.52]), psychosocial problems (Hedge’s g = 0.46 [95%CI 0.33–0.58]), and attention problems (Hedge’s g = 0.48 [95%CI 0.34–0.63]) compared to normal/healthy control subjects. There was no significant difference in the rates of neurobehavioral impairment between children with and without history of cranial radiotherapy. Conclusions: PBTS are at elevated risk of neurobehavioral impairment. Neurobehavioral monitoring should be considered as the standard of care for PBTS.

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Response assessment in pediatric neurooncology (RAPNO) criteria revisited: a practical navigation guide for neuroradiologists

Geraldo,

Maldonado,

Severino

et al. 2024

Neuroradiology

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Adaptive behavior impaired in children with low‐grade glioma

Abstract: At the group level, adaptive functioning of children with LGG is impaired compared with family controls. Regular structured monitoring of adaptive behavior is recommended to be able to define the needs for tailored rehabilitation in daily life at home as well as at school.

Cited by 8 publications

References 32 publications

Determinants of impairments in functioning, fatigue, and participation ability in pediatric brain tumor survivors

Determinants of impairments in functioning, fatigue, and participation ability in pediatric brain tumor survivors

Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis

Response assessment in pediatric neurooncology (RAPNO) criteria revisited: a practical navigation guide for neuroradiologists

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