Controlling the GOP (group of picture) size in distributed video coding is an important task since it has significant impact on the video coding performance. This paper presents a method to control the GOP size in the distributed video coding based on the Distortion-Quantization optimal and frame activity. To perform GOP size control adaptively ,firstly this work compute the frame activity in current frame of video sequence, which take GOP size and frame scene changes in frame into account at the same time. Then, the GOP size control method is obtained based on the computation of the best Distortion-Quantization parameter and the frame activity. Experimental results show that the proposed method not only achieves notable video quality improvements, but also reduced the average distortion, comparisons with the conventional scheme.