Adaptive optics ophthalmoscopy: a systematic review of vascular biomarkers

Bakker, Elise; Dikland, Felix Anne; Bakel, Roan van; Jesus, Danilo Andrade De; Brea, Luisa Sánchez; Klein, Stefan; Walsum, Theo van; Rossant, Florence; Farías, Daniela Castro; Grieve, Kate; Pâques, Michel

doi:10.1016/j.survophthal.2021.05.012

Cited by 33 publications

(41 citation statements)

References 71 publications

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“…Coupling OCTA and adaptive optics may be an exciting avenue. Adaptive optics is another novel ocular imaging approach that provides in vivo ultra-high-resolution imaging of retinal vessel morphology in humans ( 30 ).…”

Section: Potential Octa Measures Of Microcirculation In Systemic Hypertensionmentioning

confidence: 99%

The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

Tan

Yao

et al. 2021

Front. Med.

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Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls.Methods: We conducted a literature search through a search of electronic databases to identify studies before 19 June 2021, which compared OCTA parameters in non-diabetic participants with systemic hypertension vs. controls. If the OCTA parameter had a minimum number of 3 studies that analyzed it, the mean difference between participants with systemic hypertension and controls were analyzed using a random-effects model.Results: We identified 11 eligible studies. At the macula, 9 studies analyzed vessel density at the superficial capillary plexus (SVD), 7 analyzed vessel density at the deep capillary plexus (DVD), and 6 analyzed the area of the superficial foveal avascular zone (FAZ). Participants with systemic hypertension had significantly lower SVD (standardized mean difference [SMD], −0.50 [−0.70, −0.30], P < 0.00001, I2 = 63%), lower DVD (SMD, −0.38 [−0.64, −0.13], P = 0.004, I2 = 67%) and larger superficial FAZ (SMD, 0.32 [0.04, 0.61], P = 0.020, I2 = 77%).Conclusion: The eyes of people with systemic hypertension have robustly lower superficial and deep vascular densities at the macula when compared to control eyes. Our results suggest that OCTA can provide information about pre-clinical microvascular changes from systemic hypertension.

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Section: Potential Octa Measures Of Microcirculation In Systemic Hypertensionmentioning

confidence: 99%

The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

Tan

Yao

et al. 2021

Front. Med.

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“…Technology of adaptive optics (AO) has been applied to retinal imaging in DR [ 48 ]. The AO-SLO camera enables us to observe retinal structure at the cellular level or the dynamics of the cell flow of the inner retina.…”

Section: Evolutions Of Contemporary Modalities In Imaging Of Drmentioning

confidence: 99%

Progress of Imaging in Diabetic Retinopathy—From the Past to the Present

Horie

Ohno‐Matsui

2022

Diagnostics

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Advancement of imaging technology in retinal diseases provides us more precise understanding and new insights into the diseases’ pathologies. Diabetic retinopathy (DR) is one of the leading causes of sight-threatening retinal diseases worldwide. Colour fundus photography and fluorescein angiography have long been golden standard methods in detecting retinal vascular pathology in this disease. One of the major advancements is macular observation given by optical coherence tomography (OCT). OCT dramatically improves the diagnostic quality in macular edema in DR. The technology of OCT is also applied to angiography (OCT angiograph: OCTA), which enables retinal vascular imaging without venous dye injection. Similar to OCTA, in terms of their low invasiveness, single blue color SLO image could be an alternative method in detecting non-perfused areas. Conventional optical photography has been gradually replaced to scanning laser ophthalmoscopy (SLO), which also make it possible to produce spectacular ultra-widefield (UWF) images. Since retinal vascular changes of DR are found in the whole retina up to periphery, it would be one of the best targets in UWF imaging. Additionally, evolvement of artificial intelligence (AI) has been applied to automated diagnosis of DR, and AI-based DR management is one of the major topics in this field. This review is trying to look back on the progress of imaging of DR comprehensively from the past to the present.

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“…There is also growing interest in the use of ophthalmic adaptive optics (AO) for retinal vascular biomarkers [125]. A significant association of the retinal vascular structure (inner and outer diameter, parietal thickness) with hypertension has been found [126,127]. Recently, Zhang et al applied automatic segmentation of microaneurysms from AO with success [128].…”

Section: Ai and Other Retinal Imaging Parametersmentioning

confidence: 99%

Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review

et al. 2022

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The healthcare burden of cardiovascular diseases remains a major issue worldwide. Understanding the underlying mechanisms and improving identification of people with a higher risk profile of systemic vascular disease through noninvasive examinations is crucial. In ophthalmology, retinal vascular network imaging is simple and noninvasive and can provide in vivo information of the microstructure and vascular health. For more than 10 years, different research teams have been working on developing software to enable automatic analysis of the retinal vascular network from different imaging techniques (retinal fundus photographs, OCT angiography, adaptive optics, etc.) and to provide a description of the geometric characteristics of its arterial and venous components. Thus, the structure of

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Adaptive optics ophthalmoscopy: a systematic review of vascular biomarkers

Cited by 33 publications

References 71 publications

The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

Progress of Imaging in Diabetic Retinopathy—From the Past to the Present

Using Artificial Intelligence to Analyse the Retinal Vascular Network: The Future of Cardiovascular Risk Assessment Based on Oculomics? A Narrative Review

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