Adaptive radiotherapy for bladder cancer reduces integral dose despite daily volumetric imaging

Kron, Tomas; Wong, J.; Rolfo, Aldo; Pham, Daniel; Cramb, Jim; Foroudi, Farshad

doi:10.1016/j.radonc.2010.07.023

Cited by 31 publications

(28 citation statements)

References 8 publications

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“…The PTV best suited for the daily bladder volume was selected after aligning the isocenter or bony anatomy of the CBCTs to the planning CT. The reported comparisons to a non-adapted treatment revealed ART to greatly spare normal tissue (Table 2, Figure 4) [47,48,51]. Acute toxicity incidence of CTCAE Grade 3 was reported for 15% and 18% of the patients in the Australian single-and multi-institutional studies, respectively [47,50].…”

Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

“…This method had been employed in one single-and two multi-institutional studies in Australia/New Zeeland and Denmark [47,48,50,51]. The first implementation was a pilot study involving 27 patients in 2008-2009 at Peter MacCallum Cancer Center, Melbourne.…”

Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

“…The first implementation was a pilot study involving 27 patients in 2008-2009 at Peter MacCallum Cancer Center, Melbourne. The study was later expanded to a multi-institutional trial involving 12 RT centers in Australia and New Zealand in 2010-2013 [47,48,50]. The Danish multicentre trial enrolled patients during 2012-2013 [51].…”

Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

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Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

et al. 2016

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Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

Section: Online Plan Selection Based Multiple Plan Cbctsmentioning

confidence: 99%

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Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

et al. 2016

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“…Over a 35 fraction course of treatment, the extra dose delivered from CBCT to the lens, brainstem and spinal cord could reach 2, 1.7 and 1.4 Gy, respectively, pushing organs above set tolerances. However, this increase in dose has to be balanced against the potential reduction in treatment volume which can potentially result in an overall reduction of integral dose as demonstrated in adaptive radiotherapy for bladder cancer …”

Section: Safetymentioning

confidence: 99%

Faculty of Radiation Oncology Position Paper on the use of Image–Guided Radiation Therapy

et al. 2016

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The development of technology such as intensity-modulated radiotherapy (IMRT), volumetric arc therapy (VMAT) and stereotactic ablative body radiotherapy (SABR) has resulted in highly conformal radiotherapy treatments. While such technology has allowed for improved dose delivery, it has also meant that improved accuracy in the treatment room is required. Image-guided radiotherapy (IGRT), the use of imaging prior to or during treatment delivery, has been shown to improve the accuracy of treatment delivery and in some circumstances, clinical outcomes. Allied with the adoption of highly conformal treatments, there is a need for stringent quality assurance processes in a multidisciplinary environment. In 2015, the Royal Australian and New Zealand College of Radiologist (RANZCR) updated its position paper on IGRT. The draft document was distributed through the membership of the Faculty of Radiation Oncology (FRO) for review and the final version was endorsed by the board of FRO. This article describes issues that radiotherapy departments throughout Australia and New Zealand should consider. It outlines the role of IGRT and reviews current clinical evidence supporting the benefit of IGRT in genitourinary, head and neck, and lung cancers. It also highlights important international publications which provide guidance on implementation and quality assurances for IGRT. A set of key recommendations are provided to guide safe and effective IGRT implementation and practice in the Australian and New Zealander context.

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“…A typical example is the additional dose received by the patient due to imaging which must be balanced against improved treatment delivery. 37 This list cannot be exhaustive but helps to illustrate the breadth of the change brought to radiotherapy practice by the introduction of new technology in general and specifically IGRT. While these changes are currently taking place it is important to plan for the future to optimise the utilisation of technology, provide appropriate training and meet the expectations of clinicians and increasingly also of patients.…”

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confidence: 99%

Adaptive radiotherapy for bladder cancer reduces integral dose despite daily volumetric imaging

Cited by 31 publications

References 8 publications

Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

Adaptive radiotherapy strategies for pelvic tumors – a systematic review of clinical implementations

Faculty of Radiation Oncology Position Paper on the use of Image–Guided Radiation Therapy

Image guidance in the radiotherapy treatment room: Can ten years of rapid development prepare us for the future?

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