Adaptive response in human lymphocytes conditioned with hydrogen peroxide before irradiation with X-rays

Cortés, Felipe; Domı́nguez, I.; Piñero, J.; Mateos, J.C.

doi:10.1093/mutage/5.6.555

Cited by 24 publications

(7 citation statements)

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“…Other observations worthy of note regarding eukaryotic adaptive responses include reports of this adaptation in vivo (4,(15)(16)(17), the variability of this reponse in human lymphocytes from different donors (18), its requirement for de novo protein synthesis (15,16), and the cross-resistance to certain agents (19)(20)(21).…”

Section: Adaptive Responses In Eukaryotesmentioning

confidence: 99%

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Adaptive Response and Oxidative Stress

Crawford¹,

Davies²

1994

Environmental Health Perspectives

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Section: Adaptive Responses In Eukaryotesmentioning

confidence: 99%

“…Cortes (20) reported the induction of an adaptive reponse in human lymphocytes by H202 that protected these cells against subsequent lethal X-irradiation. Reports in the literature describe a number of similar cross-resistant examples.…”

Section: Oxidative Stressmentioning

confidence: 99%

Adaptive Response and Oxidative Stress

Crawford¹,

Davies²

1994

Environmental Health Perspectives

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“…38 Recently, many efforts have been made to prove LDR can induce ARs. 12,39 An LDR-induced AR is a phenomenon in which pre-exposure of cells to LDR (inductive dose, D1) renders cells more resistant to damage from subsequent HDR (challenge dose, D2) or other toxic agents. 14 In this section, we focus on the efforts and achievements made by Chinese researchers on AR and LDR-associated mechanisms of induction, especially for immune and hematopoietic systems (Figure 1).…”

Section: Low-dose Radiation–induced Arsmentioning

confidence: 99%

Research Progress on the Biological Effects of Low-Dose Radiation in China

Wang

et al. 2019

Dose-Response

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Human are exposed to ionizing radiation from natural and artificial sources, which consequently poses a possible risk to human health. However, accumulating evidence indicates that the biological effects of low-dose radiation (LDR) are different from those of high-dose radiation (HDR). Low-dose radiation–induced hormesis has been extensively observed in different biological systems, including immunological and hematopoietic systems. Adaptive responses in response to LDR that can induce cellular resistance to genotoxic effects from subsequent exposure to HDR have also been described and researched. Bystander effects, another type of biological effect induced by LDR, have been shown to widely occur in many cell types. Furthermore, the influence of LDR-induced biological effects on certain diseases, such as cancer and diabetes, has also attracted the interest of researchers. Many studies have suggested that LDR has the potential antitumor and antidiabetic complications effects. In addition, the researches on whether LDR could induce stochastic effects were also debated. Studies on the biological effects of LDR in China started in 1970s and considerable progress has been made since. In the present article, we provide an overview of the research progress on the biological effects of LDR in China.

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“…Even ten minutes after the pretreatment of CHO cells with H 2 O 2 a cross-resistance to N- methyl -N ′ - nitro -N- nitrosoguanidine (MNNG) and γ-irradiation was reported; however, the cells were not cross-resistant to UV light [174]. The adaptive response induced by H 2 O 2 was observed in human lymphocytes to protect these cells against otherwise lethal X-ray irradiation [145]. Some molecular changes were observed during the stress adaptation.…”

Section: Adaptive Response and Cross-resistancementioning

confidence: 99%

Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use

Milisav

Poljšak

Šuput

2012

IJMS

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Organisms and their cells are constantly exposed to environmental fluctuations. Among them are stressors, which can induce macromolecular damage that exceeds a set threshold, independent of the underlying cause. Stress responses are mechanisms used by organisms to adapt to and overcome stress stimuli. Different stressors or different intensities of stress trigger different cellular responses, namely induce cell repair mechanisms, induce cell responses that result in temporary adaptation to some stressors, induce autophagy or trigger cell death. Studies have reported life-prolonging effects of a wide variety of so-called stressors, such as oxidants, heat shock, some phytochemicals, ischemia, exercise and dietary energy restriction, hypergravity, etc. These stress responses, which result in enhanced defense and repair and even cross-resistance against multiple stressors, may have clinical use and will be discussed, while the emphasis will be on the effects/cross-effects of oxidants.

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Adaptive response in human lymphocytes conditioned with hydrogen peroxide before irradiation with X-rays

Cited by 24 publications

References 0 publications

Adaptive Response and Oxidative Stress

Adaptive Response and Oxidative Stress

Research Progress on the Biological Effects of Low-Dose Radiation in China

Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use

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